ChemicalBook >>Actinomycin D>>Actinomycin D(50-76-0)

Actinomycin D(50-76-0)

Actinomycin D(50-76-0)
Product IdentificationBack to Contents
【Product Name】

Actinomycin D
【Synonyms】

3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-
Actinomycin C1
Actinomycin D
Actinomycin I
Actinomycin I1
Actinomycin X 1
【CAS】

50-76-0
【Formula】

C62H86N12O16
【Molecular Weight】

1255.44
【EINECS】

200-063-6
【RTECS】

AU1575000
【RTECS Class】

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product; Primary Irritant
【Merck】

12,2867
【Beilstein/Gmelin】

605235
Physical and Chemical PropertiesBack to Contents
【Appearance】

Bright red crystalline powder.
【Solubility in water】

1 g in 25 ml of @ 10 C
【Melting Point】

246 - 247
【pKa/pKb】

11.90 (pKa)
【Partition Coefficient】

3.21 @ pH of 7.4
【Usage】

Medication (vet).
First Aid MeasuresBack to Contents
【Ingestion】

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
【Inhalation】

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. DO NOT use mouth-to-mouth respiration.
【Skin】

Get medical aid if irritation develops or persists. Wash clothing before reuse. Flush skin with plenty of soap and water. Destroy contaminated shoes.
【Eyes】

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Handling and StorageBack to Contents
【Storage】

Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C).
【Handling】

Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Hazards IdentificationBack to Contents
【Ingestion】

May be fatal if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause loss of hearing. May cause neuromuscular paralysis.
【Inhalation】

May cause respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation may produce coughing, nausea, and pulmonary edema.
【Skin】

May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
【Eyes】

May cause severe eye irritation. May cause eye injury.
【Hazards】

Contact with metals may evolve flammable hydrogen gas.
【UN (DOT)】

2811
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Fire Fighting MeasuresBack to Contents
【Flash Point】

241
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
【Fire Potential】

This material is probably combustible.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Wash area with soap and water. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability and ReactivityBack to Contents
【Stability】

Stable under normal temperatures and pressures.
【Incompatibilities】

Strong oxidizing agents, strong bases, strong acids
【Decomposition】

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
【Combustion Products】

Fire may produce irritating, corrosive and/or toxic gases.
Transport InformationBack to Contents
【UN Number】

2811
【Hazard Class】

6.1
【Packing Group】

I; II; III
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