| 中文名 | 盐酸依伐布雷定
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| 英文名 | Ivabradine hydrochloride
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| 别名 | 盐酸伊伐布雷
盐酸伊伐布雷定
盐酸依伐布雷定
盐酸伊伐布雷啶
盐酸依法布雷定
依伐布雷定盐酸盐
盐酸伊伐布雷定及中间体
盐酸伊伐布雷定(依法布雷定)
盐酸伊伐布雷定IVABRADINE(研发中)
3-[3-[[(8S)-3,4-二甲氧基-8-双环[4.2.0]辛-1,3,5-三烯]甲基-甲氨基]丙基]-7,8-二甲氧基-2,5-二氢-1H-3-苯并氮杂卓-4-酮盐酸盐
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| 英文别名 | Corlentor
Ivabradine HCl
Ivabradine hydrochloride
IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR
3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride
3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
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| CAS | 148849-67-6
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| EINECS | 638-798-3 |
| 化学式 | C27H36N2O5.HCl
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| 分子量 | 505.05 |
| InChI | InChI=1/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1 |
| InChIKey | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
| 熔点 | 193-196?C |
| 沸点 | 626.9°C at 760 mmHg |
| 比旋光度 | 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO) |
| 闪点 | 332.9°C |
| 蒸汽压 | 1.24E-15mmHg at 25°C |
| 溶解度 | H2O: ≥ 5mg/ml (温热) |
| 存储条件 | 2-8°C |
| 外观 | 粉末 |
| 颜色 | white to beige |
| Merck | 14,5247 |
| MDL号 | MFCD00929899 |
| 体内研究 | Ivabradine hydrochloride treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression. Ivabradine hydrochloride leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine hydrochloride treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension. |
| 危险品标志 | N - 危害环境的物品
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| 风险术语 | 50/53 - 对水生生物有极高毒性，可能对水体环境产生长期不良影响。
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| 安全术语 | S60 - 该物质及其容器须作为危险性废料处置。
S61 - 避免释放至环境中。参考特别说明/安全数据说明书。
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| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| 上游原料 | 脱氢伊伐布雷定 (1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐 |