5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide
![5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide price.](/CAS/20180529/GIF/1451993-15-9.gif)
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- $59 - $1200
- Product name: 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide
- CAS: 1451993-15-9
- MF: C17H15F3N4O3S2
- MW: 444.45
- EINECS:-0
- MDL Number:
- Synonyms:5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide;VU0467154;VU0467154, VU-0467154, VU 0467154;Thieno[2,3-c]pyridazine-6-carboxamide, 5-amino-3,4-dimethyl-N-[[4-[(trifluoromethyl)sulfonyl]phenyl]methyl]-;VUO467154 - M4 Receptor Agonist;VU0467154,Muscarinic acetylcholine receptor,VU 0467154,VU-0467154,mAChR,inhibit,Inhibitor
11 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number7603DW
- Product descriptionCID73774630
- Packaging1mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25555
- Product descriptionVU0467154 ≥95%
- Packaging1mg
- Price$59
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25555
- Product descriptionVU0467154 ≥95%
- Packaging5mg
- Price$239
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25555
- Product descriptionVU0467154 ≥95%
- Packaging10mg
- Price$421
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25555
- Product descriptionVU0467154 ≥95%
- Packaging25mg
- Price$979
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0044134
- Product descriptionVU0467154 99.59%
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0044134
- Product descriptionVU0467154 99.59%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0044134
- Product descriptionVU0467154 99.59%
- Packaging25mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0044134
- Product descriptionVU0467154 99.59%
- Packaging50mg
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0044134
- Product descriptionVU0467154 99.59%
- Packaging100mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberV850025
- Product descriptionVU0467154
- Packaging100mg
- Price$1200
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 7603DW | CID73774630 | 1mg | $162 | 2021-12-16 | Buy |
| Cayman Chemical | 25555 | VU0467154 ≥95% | 1mg | $59 | 2024-03-01 | Buy |
| Cayman Chemical | 25555 | VU0467154 ≥95% | 5mg | $239 | 2024-03-01 | Buy |
| Cayman Chemical | 25555 | VU0467154 ≥95% | 10mg | $421 | 2024-03-01 | Buy |
| Cayman Chemical | 25555 | VU0467154 ≥95% | 25mg | $979 | 2024-03-01 | Buy |
| ChemScene | CS-0044134 | VU0467154 99.59% | 5mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-0044134 | VU0467154 99.59% | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0044134 | VU0467154 99.59% | 25mg | $290 | 2021-12-16 | Buy |
| ChemScene | CS-0044134 | VU0467154 99.59% | 50mg | $490 | 2021-12-16 | Buy |
| ChemScene | CS-0044134 | VU0467154 99.59% | 100mg | $850 | 2021-12-16 | Buy |
| TRC | V850025 | VU0467154 | 100mg | $1200 | 2021-12-16 | Buy |
Properties
Density :1.514±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: Soluble
form :A solid
pka :11.80±0.46(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: Soluble
form :A solid
pka :11.80±0.46(Predicted)
Safety Information
| Symbol(GHS): |
  
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| Signal word: | Danger | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Description
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor that potentiates acetylcholine responses in CHO cells expressing M4 receptors (EC50s = 17.7, 630, and 1,000 nM for rat, human, and cynomolgus monkey receptors, respectively). It is selective for M4 over M1-3 and M5 receptors and a panel of receptors, transporters, and cation channels when used at a concentration of 10 μM. In vivo, VU0467154 (3-56.6 mg/kg, p.o.) reverses amphetamine-induced hyperlocomotion in rats. It reverses MK-801-induced hyperlocomotion, deficits in a pairwise visual discrimination task, and impairments in the acquisition of contextual fear conditioning in wild-type, but not M4 knockout, mice. VU0467154 (3-30 mg/kg) also increases freezing behavior in contextual and tone fear conditioning tests in wild-type mice when administered prior to the conditioning session. Chronic administration of VU0467154 (10 mg/kg once daily) reduces motor incoordination and prevents decreases in locomotion in the YAC128 transgenic mouse model of Huntington''s disease.More related product prices
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