VU0483605
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- $49 - $942
- Product name: VU0483605
- CAS: 1623101-11-0
- MF: C20H10Cl3N3O3
- MW: 446.67
- EINECS:
- MDL Number:MFCD29770792
- Synonyms:VU0483605;2-Chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)phenyl]nicotinamide;3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide;3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide;2-Pyridinecarboxamide, 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-;3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]pyridine-2-carboxamide;3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide;Inhibitor,inhibit,VU0483605,Metabotropic glutamate receptors,allosteric modulator,brain penetrant,metabotropic glutamate,VU 0483605,mGluR,VU-0483605
11 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- Chemenu
- Crysdot
- TRC
Package
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5042
- Product descriptionVU0483605
- Packaging10mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5042
- Product descriptionVU0483605
- Packaging50mg
- Price$585
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC5611
- Product descriptionVU0483605
- Packaging10mg
- Price$171
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16941
- Product descriptionVU0483605 ≥98%
- Packaging1mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16941
- Product descriptionVU0483605 ≥98%
- Packaging5mg
- Price$96
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16941
- Product descriptionVU0483605 ≥98%
- Packaging10mg
- Price$143
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM268069
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 95%+
- Packaging1g
- Price$888
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00008504
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97%
- Packaging100mg
- Price$236
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00008504
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97%
- Packaging250mg
- Price$376
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00008504
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97%
- Packaging1g
- Price$942
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberV787575
- Product descriptionVU0483605
- Packaging50mg
- Price$550
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5042 | VU0483605 | 10mg | $175 | 2021-12-16 | Buy |
| AK Scientific | SYN5042 | VU0483605 | 50mg | $585 | 2021-12-16 | Buy |
| ApexBio Technology | C5611 | VU0483605 | 10mg | $171 | 2021-12-16 | Buy |
| Cayman Chemical | 16941 | VU0483605 ≥98% | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 16941 | VU0483605 ≥98% | 5mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 16941 | VU0483605 ≥98% | 10mg | $143 | 2024-03-01 | Buy |
| Chemenu | CM268069 | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 95%+ | 1g | $888 | 2021-12-16 | Buy |
| Crysdot | CD00008504 | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97% | 100mg | $236 | 2021-12-16 | Buy |
| Crysdot | CD00008504 | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97% | 250mg | $376 | 2021-12-16 | Buy |
| Crysdot | CD00008504 | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97% | 1g | $942 | 2021-12-16 | Buy |
| TRC | V787575 | VU0483605 | 50mg | $550 | 2021-12-16 | Buy |
Properties
Density :1.625±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :crystalline solid
pka :9.39±0.70(Predicted)
storage temp. :Store at -20°C
solubility :≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :crystalline solid
pka :9.39±0.70(Predicted)
Safety Information
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Description
Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced receptor activation. VU0483605 is a selective positive allosteric modulator (PAM) of mGluR1, displaying EC50 values of 0.39 and 0.36 μM at human and rat receptors, respectively, and no activity as a mGlu4 PAM (EC50 >10 μM). It has been shown to potentiate a response to glutamate in wild-type cell lines stably expressing mGlu1 and to partially restore the reduction in glutamate-mediated calcium signaling in a mutant cell model of schizophrenia.More related product prices
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