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ChemicalBook >> CAS DataBase List >> PFI-1

PFI-1

$23 - $2691.1
Product name: PFI-1
CAS: 1403764-72-6
MF: C16H17N3O4S
MW: 347.39
EINECS:
MDL Number:MFCD22580416
Synonyms:PFI-1;PFI-1 (PF-6405761);PFI-1 (PF-06405761);PF-06405761;Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-;2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide PFI-1 (PF-6405761);2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-bezenesulfonamide;PFI-1;PFI-1;PFI 1;PFI1

Price44 Properties Safety Information Description

44 prices

Selected condition：

Brand

AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Biorbyt Ltd
BroadPharm
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Medical Isotopes, Inc.
Sigma-Aldrich
Tocris
TRC
Usbiological

Package

50
1mg
5mg
10
10mg
25mg
50mg
100mg
200mg
250mg
1g

ManufacturerAK Scientific
Product numberSYN3009
Product descriptionPF-06405761
Packaging10mg
Price$175
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA280183
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
Packaging1mg
Price$23
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA280183
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
Packaging5mg
Price$47
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA280183
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
Packaging10mg
Price$67
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA280183
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
Packaging50mg
Price$185
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA280183
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
Packaging100mg
Price$260
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA280183
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
Packaging250mg
Price$545
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA280183
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%
Packaging1g
Price$1311
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberINB0001877
Product description2-METHOXY-N-(3-METHYL-2-OXO-1,2,3,4-TETRAHYDRO-QUINAZOLIN-6-YL)-BEZENESULFONAMIDE 95.00%
Packaging5MG
Price$502.71
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA4184
Product descriptionPFI-1(PF-6405761)
Packaging10mg
Price$60
Updated2021-12-16
Buy

ManufacturerArctom
Product numberAS504591
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%
Packaging1mg
Price$23
Updated2021-12-16
Buy

ManufacturerArctom
Product numberAS504591
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%
Packaging5mg
Price$47
Updated2021-12-16
Buy

ManufacturerArctom
Product numberAS504591
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%
Packaging10mg
Price$66
Updated2021-12-16
Buy

ManufacturerArctom
Product numberAS504591
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%
Packaging50mg
Price$183
Updated2021-12-16
Buy

ManufacturerArctom
Product numberAS504591
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%
Packaging100mg
Price$257
Updated2021-12-16
Buy

ManufacturerArctom
Product numberAS504591
Product description2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%
Packaging250mg
Price$540
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	SYN3009	PF-06405761	10mg	$175	2021-12-16	Buy
Ambeed	A280183	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%	1mg	$23	2021-12-16	Buy
Ambeed	A280183	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%	5mg	$47	2021-12-16	Buy
Ambeed	A280183	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%	10mg	$67	2021-12-16	Buy
Ambeed	A280183	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%	50mg	$185	2021-12-16	Buy
Ambeed	A280183	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%	100mg	$260	2021-12-16	Buy
Ambeed	A280183	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%	250mg	$545	2021-12-16	Buy
Ambeed	A280183	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide 98+%	1g	$1311	2021-12-16	Buy
American Custom Chemicals Corporation	INB0001877	2-METHOXY-N-(3-METHYL-2-OXO-1,2,3,4-TETRAHYDRO-QUINAZOLIN-6-YL)-BEZENESULFONAMIDE 95.00%	5MG	$502.71	2021-12-16	Buy
ApexBio Technology	A4184	PFI-1(PF-6405761)	10mg	$60	2021-12-16	Buy
Arctom	AS504591	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%	1mg	$23	2021-12-16	Buy
Arctom	AS504591	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%	5mg	$47	2021-12-16	Buy
Arctom	AS504591	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%	10mg	$66	2021-12-16	Buy
Arctom	AS504591	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%	50mg	$183	2021-12-16	Buy
Arctom	AS504591	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%	100mg	$257	2021-12-16	Buy
Arctom	AS504591	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide ≥98%	250mg	$540	2021-12-16	Buy

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Properties

storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
color :white to beige

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Bromodomains recognize acetylated lysine residues and recruit regulatory complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The isolated individual or tandem bromodomains of bromodomain-containing protein (BRD) 2 and BRD4 bind acetylated histone tails, which couples histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of bromodomain interactions hold promise as useful therapeutics for human disease. PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. In an AlphaScreen assay it has been shown to inhibit BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC50 values of 98 nM and 0.22 μM, respectively. See the Structural Genomics Consortium (SGC) website for more information.

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