QUINOMYCIN A
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- $97 - $1365
- Product name: QUINOMYCIN A
- CAS: 512-64-1
- MF: C51H64N12O12S2
- MW: 1101.26
- EINECS:
- MDL Number:MFCD00156105
- Synonyms:echinomycina ;nsc526417 ;ECHINOMYCIN;N-[(1R,4S,8R,11S,14R,17S,21R,24S)-3,11,13,16,24,26-hexamethyl-27-methylsulfanyl-2,5,9,12,15,18,22,25-octaoxo-4,17-di(propan-2-yl)-8-(quinoxaline-2-carbonylamino)-6,19-dioxa-28-thia-3,10,13,16,23,26-hexazabicyclo[12.12.3]nonacosan-21-yl]quinoxaline-2-carbo;N-(2-Quinoxalinylcarbonyl)cyclo(D-Ser*-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-N-(quinoxaline-2-ylcarbonyl)-D-Ser*-Ala-N-methyl-3-methylthio-L-Ala(1)-N-methyl-L-Val-);SK-302B;Echinomycin >97%;N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl L-valine (81)-lactone cyclic (37)-thioester
11 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1
- 1MG
- 2.5mg
- 5mg
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0267-M005
- Product descriptionEchinomycin ≥98%(HPLC)
- Packaging5mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2677AH
- Product descriptionQuinomycinA
- Packaging5mg
- Price$473
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0010197
- Product descriptionQUINOMYCIN A 95.00%
- Packaging1MG
- Price$1365
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11049
- Product descriptionEchinomycin ≥98%
- Packaging1mg
- Price$97
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11049
- Product descriptionEchinomycin ≥98%
- Packaging5mg
- Price$360
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0024860
- Product descriptionEchinomycin ≥98.0%
- Packaging1mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0477
- Product descriptionEchinomycin ≥98% (HPLC)
- Packaging1mg
- Price$142
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0477
- Product descriptionEchinomycin ≥98% (HPLC)
- Packaging5mg
- Price$588
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number5520
- Product descriptionEchinomycin ≥98%(HPLC)
- Packaging1
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberQ765503
- Product descriptionQuinomycinA
- Packaging2.5mg
- Price$545
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product numberQ1101
- Product descriptionQuinomycin A
- Packaging1mg
- Price$339
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | BVT-0267-M005 | Echinomycin ≥98%(HPLC) | 5mg | $300 | 2021-12-16 | Buy |
| AK Scientific | 2677AH | QuinomycinA | 5mg | $473 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010197 | QUINOMYCIN A 95.00% | 1MG | $1365 | 2021-12-16 | Buy |
| Cayman Chemical | 11049 | Echinomycin ≥98% | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 11049 | Echinomycin ≥98% | 5mg | $360 | 2024-03-01 | Buy |
| ChemScene | CS-0024860 | Echinomycin ≥98.0% | 1mg | $250 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML0477 | Echinomycin ≥98% (HPLC) | 1mg | $142 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0477 | Echinomycin ≥98% (HPLC) | 5mg | $588 | 2024-03-01 | Buy |
| Tocris | 5520 | Echinomycin ≥98%(HPLC) | 1 | $118 | 2021-12-16 | Buy |
| TRC | Q765503 | QuinomycinA | 2.5mg | $545 | 2021-12-16 | Buy |
| Usbiological | Q1101 | Quinomycin A | 1mg | $339 | 2021-12-16 | Buy |
Properties
Melting point :217-218℃
alpha :D20 -310° (c = 0.86 in chloroform)
Boiling point :1427.2±65.0 °C(Predicted)
Density :1.0964 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :9.38±0.70(Predicted)
form :White solid
color :white to beige
Merck :13,3531
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
alpha :D20 -310° (c = 0.86 in chloroform)
Boiling point :1427.2±65.0 °C(Predicted)
Density :1.0964 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :9.38±0.70(Predicted)
form :White solid
color :white to beige
Merck :13,3531
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription. It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the hypoxia-responsive element. Echinomycin reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50 value of 1.2 nM. It inhibits hypoxia-induced expression of vascular endothelial growth factor, blocking angiogenesis and altering excitatory synaptic transmission in hippocampal neurons. Echinomycin also impairs expression of survivin, enhancing the sensitivity of multiple myeloma cells to melphalan.More related product prices
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