![](/CAS/GIF/4964-49-2.gif)
1-(2-AMINOPHENYL)ETHAN-1-ONE OXIME synthesis
- Product Name:1-(2-AMINOPHENYL)ETHAN-1-ONE OXIME
- CAS Number:4964-49-2
- Molecular formula:C8H10N2O
- Molecular Weight:150.18
![2-Aminoacetophenone](/CAS/GIF/551-93-9.gif)
551-93-9
466 suppliers
$6.00/5g
![1-(2-AMINOPHENYL)ETHAN-1-ONE OXIME](/CAS/GIF/4964-49-2.gif)
4964-49-2
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Yield:4964-49-2 90.3%
Reaction Conditions:
with hydroxylamine hydrochloride in ethanol at 80;Temperature;Concentration;
Steps:
4 Embodiment 4 of formula (VI) as shown in the synthesis of the compounds
For 500 ml is provided with a condensation return line, a thermometer in the four flasks are sequentially added ortho-amino-acetophenone 27g (0.2 μM), hydroxylamine hydrochloride 18.5g (0.266 μM), anhydrous ethanol 240 ml, 85 °C reflux, HPLC monitoring reaction; then cool to 20 °C, dropping 10% sodium carbonate solution, adjusting the pH=7.0 of the reaction solution, then the liquid is cooled to 10 °C, adding proper amount of water, the reaction solution becomes turbid, standing; then drop by almost 480 ml water, for 8 °C nourishing crystal 60 minutes; filtering, washing ethanol - water system, vacuum drying, get 27.09g white solid (VI) compound of formula, molar yield 90.3%, HPLC (%): 99.1%.
References:
CN104892609,2017,B Location in patent:Paragraph 0115; 0118; 0121; 0122; 0123; 0124
![2'-AMINOACETOPHENONE HYDROCHLORIDE](/CAS/GIF/25384-14-9.gif)
25384-14-9
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$7.00/250mg
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![Hydrochloric acid](/CAS/GIF/7647-01-0.gif)
7647-01-0
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$10.00/10g
![methazonic acid](/CAS/GIF/5653-21-4.gif)
5653-21-4
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![2-Aminoacetophenone](/CAS/GIF/551-93-9.gif)
551-93-9
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$6.00/5g
![4-METHYL-3-NITROQUINOLINE](/CAS/GIF/79965-62-1.gif)
79965-62-1
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$21.00/100mg
![1-(2-AMINOPHENYL)ETHAN-1-ONE OXIME](/CAS/GIF/4964-49-2.gif)
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![1,2,3-Benzotriazine, 4-methyl-, 3-oxide](/CAS/20210305/GIF/41608-06-4.gif)
41608-06-4
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![HYDROXYLAMINE](/CAS/GIF/7803-49-8.gif)
7803-49-8
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$14.00/5mL
![Sodium ethoxide](/CAS/GIF/141-52-6.gif)
141-52-6
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$10.00/5g
![1-(2-AMINOPHENYL)ETHAN-1-ONE OXIME](/CAS/GIF/4964-49-2.gif)
4964-49-2
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![Hydrochloric acid](/CAS/GIF/7647-01-0.gif)
7647-01-0
11 suppliers
$10.00/10g
![methazonic acid](/CAS/GIF/5653-21-4.gif)
5653-21-4
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![Water](/CAS/GIF/7732-18-5.gif)
7732-18-5
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$13.50/100ML
![2-Aminoacetophenone](/CAS/GIF/551-93-9.gif)
551-93-9
466 suppliers
$6.00/5g
![4-METHYL-3-NITROQUINOLINE](/CAS/GIF/79965-62-1.gif)
79965-62-1
29 suppliers
$21.00/100mg
![1-(2-AMINOPHENYL)ETHAN-1-ONE OXIME](/CAS/GIF/4964-49-2.gif)
4964-49-2
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