ChemicalBook CAS DataBase List 1-(3-METHOXY-4-METHYLPHENYL)ETHAN-1-ONE

1-(3-METHOXY-4-METHYLPHENYL)ETHAN-1-ONE synthesis

10synthesis methods

Product Name:1-(3-METHOXY-4-METHYLPHENYL)ETHAN-1-ONE
CAS Number:3556-81-8
Molecular formula:C10H12O2
Molecular Weight:164.2

3556-60-3
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$17.00/1g

3556-81-8
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$45.00/50mg

Yield:3556-81-8 99%

Reaction Conditions:

with hydrogenchloride in CH₃ MgI;diethyl ether;

Steps:

P.13 Preparation of Benzylamine Derivative

This 3-methoxy-4-methylcyanobenzene in the amount of 35 grams (238 millimoles) was mixed with 43.5 grams (262 millimoles) of CH₃ MgI and then heated under reflux for 4.5 hours in 200 milliliters of diethyl ether. Then, to the reaction product thus obtained, 300 milliliters of 6 Normal hydrochloric acid was added, and the resulting mixture was heated under reflux for 1 hour. A diethyl ether layer was separated, washed with water and then dried over anhydrous sodium sulfate. Subsequently the diethyl ether was distilled away under reduced pressure. Thus, as a product, 39.0 grams (238 millimoles) of 3-methoxy-4-methylacetophenone was obtained (yield, 99%).

References:

US4680054,1987,A