ChemicalBook CAS DataBase List 1-methyl-2-phenylbenzimidazole

1-methyl-2-phenylbenzimidazole synthesis

13synthesis methods

Product Name:1-methyl-2-phenylbenzimidazole
CAS Number:2622-63-1
Molecular formula:C14H12N2
Molecular Weight:208.26

612-28-2
130 suppliers
$15.00/1 g

2835-06-5 Synthesis

2835-06-5
284 suppliers
$6.00/25g

2622-63-1
16 suppliers
$65.00/100mg

Yield: 79%

Reaction Conditions:

with potassium carbonate in toluene at 140; for 24 h;Schlenk technique;Sealed tube;

Steps:

12 Embodiment 12
In a clean dry 10 ml Schlenk reaction tube, sequentially adding a 2-nitro-N-methylaniline 38 mg, benzene glycine 113 mg, potassium carbonate 80 mg, in order to 1 ml of toluene as a solvent, the reaction tube seal, in 140 °C reaction under 24 hours. After the reaction, the reaction mixture directly by rotating the evaporimeter turns on lathe does, then the volume ratio of 8:1 of petroleum ether and ethyl acetate as the eluant, by separating by silica gel column, to obtain 39 mg light yellow solid, yield 79%.

References:

Xinyang Normal University;Tang, Lin;Tan, Meirong CN105777662, 2016, A Location in patent:Paragraph 0090; 0091; 0092

1632-83-3 Synthesis