ethyl 5-bromo-3-((ethoxycarbonyl)amino)benzofuran-2-carboxylate synthesis
- Product Name:ethyl 5-bromo-3-((ethoxycarbonyl)amino)benzofuran-2-carboxylate
- CAS Number:1251582-36-1
- Molecular formula:C14H14BrNO5
- Molecular Weight:356.17
541-41-3
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Yield:1251582-36-1 100%
Reaction Conditions:
in toluene;acetonitrile;Reflux;
Steps:
38.1
A mixture of the benzofuran 38a (prepared using the method of Example 1, step 1 but replacing compound 1a with 4-bromo-2-cyanophenol, and replacing compound 1b with ethyl 2-bromoacetate (6.0 g, 1 eq) in toluene/acetonitrile (75 mL/45 mL) and ethyl chloroformate (10 mL, 5 eq) is heated at reflux overnight, then concentrated under reduced pressure to give compound 38b (7.4 g, 100%).
References:
US2010/261714,2010,A1 Location in patent:Page/Page column 64
40530-18-5
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