ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride synthesis
- Product Name:ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
- CAS Number:175406-94-7
- Molecular formula:C14H17NO3
- Molecular Weight:247.29
40114-49-6
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175406-94-7
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Yield: 99%
Reaction Conditions:
with sodium hydride for 0.333333 h;Heating / reflux;
Steps:
51.1
[0248] To a stirred mixture of l-benzylpiperidin-3-one (72 g) and dimethyl carbonate (500 mL) was added NaH (38 g, 60%). After 20 minutes at reflux, water (800 mL) was added. The resulting solution was extracted with ethyl acetate (3 x 400 mL), dried over sodium sulfate and concentrated to give methyl l-benzyl-3- oxopiperidine-4-carboxylate as a brown oil (93 g, 99%). LCMS: 248 (M+H) +.
References:
KALYPSYS, INC. WO2009/26241, 2009, A1 Location in patent:Page/Page column 77-78
67-56-1
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39514-19-7
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175406-94-7
44 suppliers
$79.00/250mg