2'-BROMO-4'-CHLOROACETANILIDE synthesis
- Product Name:2'-BROMO-4'-CHLOROACETANILIDE
- CAS Number:57045-85-9
- Molecular formula:C8H7BrClNO
- Molecular Weight:248.5
Yield:57045-85-9 99%
Reaction Conditions:
with dmap in chloroform; for 6 h;Reflux;
Steps:
N-Acetylation; General Procedure
General procedure: In a 50-mL, round-bottom flask, aniline (5.0 mmol, 1.0 equiv) was dissolved in CHCl3 (20 mL), followed by addition of DMAP (0.031 g, 0.25 mmol, 5 mol%). Ac2O (0.51 g, 5.0 mmol, 1.0 equiv) was added dropwise, and the mixture was stirred at reflux temperature (TLC monitoring) until completion. The mixture was cooled to r.t. and washed with distilled water. The organic layer was dried (anhyd MgSO4), followed by removal of solvent under reduced pressure to obtain the crude product, which was purified by flash chromatography (EtOAc/n-hexane).
References:
Baek, Junghyun;Ban, Jaeyoung;Lim, Minkyung;Rhee, Hakjune;Shabbir, Saira [Synthesis,2020,vol. 52,# 6,p. 917 - 927]
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