2-Chloro-4-MethoxybenzylaMine synthesis

Yield:247569-72-8 91.4%

Reaction Conditions:

with sulfuryl dichloride;acetic acid at 20 - 25; for 3 h;

Steps:

3

3 kg of 4-methoxybenzylamine was weighed into a 50 L reaction vessel, 30 L of acetic acid was added, 3.015 kg of sulfonyl chloride was added dropwise at room temperature, and the reaction was carried out at 25 ° C for 3 hours, cooled to 0-5 degrees, and filtered to obtain a crude product. The product was recrystallized by the addition of 15 L of ethyl acetate to give 4.16 g,yield: 91.4%, purity: 99.5%.

References:

CN108395377,2018,A Location in patent:Paragraph 0003; 0013-0016