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ChemicalBook CAS DataBase List 2-(chloromethyl)-1-methylpiperidine

2-(chloromethyl)-1-methylpiperidine synthesis

3synthesis methods
-

Yield:49665-74-9 58%

Reaction Conditions:

with thionyl chloride in dichloromethane; for 7 h;Reflux;Inert atmosphere;

References:

Whitehouse, Andrew J.;Thomas, Sherine E.;Brown, Karen P.;Fanourakis, Alexander;Chan, Daniel S.-H.;Libardo, M. Daben J.;Mendes, Vitor;Boshoff, Helena I. M.;Floto, R. Andres;Abell, Chris;Blundell, Tom L.;Coyne, Anthony G. [Journal of Medicinal Chemistry,2019,vol. 62,# 15,p. 7210 - 7232] Location in patent:supporting information