ChemicalBook CAS DataBase List 2-Chloroquinoxaline

2-Chloroquinoxaline synthesis

13synthesis methods

Product Name:2-Chloroquinoxaline
CAS Number:1448-87-9
Molecular formula:C8H5ClN2
Molecular Weight:164.59

1196-57-2 Synthesis

1196-57-2
314 suppliers
$6.00/10g

1448-87-9
152 suppliers
$10.00/500mg

Yield:1448-87-9 93%

Reaction Conditions:

with trichlorophosphate in toluene; for 1 h;Reflux;

Steps:

0 Step 0: Preparation of Precursor Quinaxoline

The chlorination of the 2-hydroxy quinoxaline was carried out in neat POCl3 (2.3 eqs) at reflux for an hour and produced the 2-chloro-quinoxaline (1D-008) in very good yield. This chemistry was tested on 100 g scale and afforded typically 103-105 g (98-99%). A quick filtration through a Pad of silica of the crude reaction mixture resulted in clean material (99% pure by LCMS). This reaction has beenscaled up to 600 g.

References:

US2017/143706,2017,A1 Location in patent:Paragraph 0050; 0106; 0107

1196-57-2 Synthesis

1196-57-2
314 suppliers
$6.00/10g

1448-87-9
152 suppliers
$10.00/500mg

References