2-Iodo-4-(trifluoroMethyl)phenol synthesis
- Product Name:2-Iodo-4-(trifluoroMethyl)phenol
- CAS Number:463976-21-8
- Molecular formula:C7H4F3IO
- Molecular Weight:288.01
402-45-9
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463976-21-8
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Yield: 75%
Reaction Conditions:
with iodine;sodium hydrogencarbonate;thiourea in tetrahydrofuran;water
Steps:
12.A 6-(5-Trifluoromethyl-3-methyl-benzofuran-2-suffonyl)-2H-pyridazin-3-one
Step A: a,a a-Trifluoro-o-iodo-p-cresol. A mixture of iodine (91.6 mmol, 23.2 g) and sodium bicarbonate (91.6 mmol, 7.7 g) was added to a solution of α,α,α-trifluoro-p-cresol (83.3 mmol, 13.5 g) in THF (90 mL) and H2O (90 mL) and the reaction mixture was allowed to stand at room temperature overnight. Sufficient thiourea (5% solution) was added to remove the excess iodine as indicated by the color change of the reaction from deep violet to brown. The reaction mixture was extracted with ether (3*100 mL), the extract was dried, filtered and the filtrate was concentrated to obtain a brown oil. This oil was distilled (bp 105° C. at 44 mm Hg) to obtain α,α,α-trifluoro-o-iodo-p-cresol (4.1 g, 75% pure, admixed with the starting α,α,α-trifluoro-p-cresol).
References:
Mylari, Banavara L. US2002/143017, 2002, A1
109-99-9
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402-45-9
339 suppliers
$20.00/5 / G
463976-21-8
63 suppliers
$45.00/10mg
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463976-21-8
63 suppliers
$45.00/10mg