ChemicalBook CAS DataBase List (2-ISOCYANOETHYL)BENZENE

(2-ISOCYANOETHYL)BENZENE synthesis

5synthesis methods

Product Name:(2-ISOCYANOETHYL)BENZENE
CAS Number:59795-89-0
Molecular formula:C9H9N
Molecular Weight:131.18

1895-39-2
284 suppliers
$6.00/5g

64-04-0
8 suppliers
$10.00/5mL

59795-89-0
48 suppliers
$180.00/1 g

Yield:59795-89-0 76%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 100; for 12 h;Inert atmosphere;

Steps:

8
Put sodium difluorochloroacetate 1 (0.2mmol, 31mg), K2CO3 (0.2mmol, 28mg) and 2-phenylethylamine (2h, 0.1mmol, 12.1mg) into a 25mL reaction tube, evacuate and fill with nitrogen (three times ). DMF (1 mL) was injected with a syringe under nitrogen protection. Stir in an oil bath at 100°C for 12 hours. After cooling to room temperature, filter and add the reaction solution and 20 mL of water to the extraction funnel, then add 25 mL of dichloromethane for extraction, and then take the organic layer and add a small amount of silica gel to spin dry column chromatography. Yellow oily product 3h (yield 76%)

References:

CN112279789, 2021, A Location in patent:Paragraph 0074-0079

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23069-99-0 Synthesis