(2-METHOXYPHENYL)-(4-METHOXYPHENYL)-METHANE synthesis

12synthesis methods

Product Name:(2-METHOXYPHENYL)-(4-METHOXYPHENYL)-METHANE
CAS Number:30567-87-4
Molecular formula:C15H16O2
Molecular Weight:228.29

529-28-2 Synthesis

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(2-METHOXYPHENYL)-(4-METHOXYPHENYL)-METHANE

30567-87-4
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Yield:30567-87-4 86%

Reaction Conditions:

with Dimethyl oxalate;1,1'-bis-(diphenylphosphino)ferrocene;manganese;1,10-Phenanthroline;[1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride in N,N-dimethyl-formamide at 80; for 30 h;Inert atmosphere;Glovebox;

Steps:

26

Add (1,1'-bis(diphenylphosphine)ferrocene) nickel dichloride (13.7mg, 0.02mmol), 1,1'-bis(diphenylphosphine)ferrocene (11.1mg, 0.02mmol), 1,10-phenanthroline (0.7mg, 0.004mmol),Dimethyl oxalate (42.5mg, 0.36mmol), manganese powder (33.2mg, 0.6mmol), then p-methoxybenzyl alcohol (27.6mg, 0.2mmol) and 2-iodoanisole (70.2mg, 0.3mmol) DMF (1mL) solution was injected into the reaction tube, plugged the flip stopper, taken out from the glove box, under inert gas protection, reacted at 80 for 30h, after the reaction, quenched with water and ethyl acetate Extraction (30mL×3), dry with anhydrous sodium sulfate, then filter and concentrate, and the concentrate is subjected to silica gel column chromatography (200-300 mesh silica gel, eluent is petroleum ether: ethyl acetate = 100mL: 1mL) to obtain 1-isopropyl-2-(4-methoxybenzyl)benzene. (Colorless oily liquid, 39.2mg, yield 86%).

References:

CN111548269,2020,A Location in patent:Paragraph 0167-0171