2-(Trifluoromethyl)phenylhydrazine hydrochloride synthesis
- Product Name:2-(Trifluoromethyl)phenylhydrazine hydrochloride
- CAS Number:3107-34-4
- Molecular formula:C7H8ClF3N2
- Molecular Weight:212.6
88-17-5
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Yield:-
Reaction Conditions:
Stage #1:2-(trifluoromethyl)benzenamine with hydrogenchloride;sodium nitrite in water at 0; for 0.5 h;
Stage #2: with sodium hydrogensulfite in water for 3 h;Reflux;
Steps:
General procedure for preparation intermediates of Phenylhydrazine hydrochloride (9a-h)
General procedure: To a mixture of substituted phenyl amine (0.06 mol) and 15% HCl (60 mL), NaNO2 (5 g, 0.072 mol) in H2O (200 mL) was added drop-wise at 0 °C. After the completion of addition, the reaction mixture was stirred at this temperature for 30 min. and then was dropped into the mixture of saturated solution of sodium hydrogen sulfite (22.5 g, 0.216 mol), keeping the reaction below 20 °C. Upon completing the addition, the reaction was heated under refluxed for 3 h and cooled to room temperature. The solid is filtered and washed with ethyl acetate and the cake was dried to give white solid 9a-h yielded 90%.
References:
Zhou, Shunguang;Ren, Jianguo;Liu, Mingmei;Ren, Lixiang;Liu, Yajing;Gong, Ping [Bioorganic Chemistry,2014,vol. 57,p. 30 - 42]
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1000210-73-0
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3107-34-4
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