ChemicalBook CAS DataBase List Carbamic acid, (2,6-dioxo-3-piperidinyl)-, phenylmethyl ester (9CI)

Carbamic acid, (2,6-dioxo-3-piperidinyl)-, phenylmethyl ester (9CI) synthesis

5synthesis methods

Product Name:Carbamic acid, (2,6-dioxo-3-piperidinyl)-, phenylmethyl ester (9CI)
CAS Number:24666-55-5
Molecular formula:C13H14N2O4
Molecular Weight:262.26

1155-62-0
353 suppliers
$10.00/5g

Carbamic acid, (2,6-dioxo-3-piperidinyl)-, phenylmethyl ester (9CI)

24666-55-5
80 suppliers
$37.00/100mg

Yield: 92%

Reaction Conditions:

with urea in dimethyl sulfoxide at 150; for 2 h;Solvent;Temperature;

Steps:

3.4
N-CBZ-L-glutamic acid 2.81 g (0.01 mol),Urea 1.2g (0.2mol) was added to DMSO to dissolve and reflux at 150 ° C. After 2 h, the temperature was lowered.HCl gas, a white solid 1.518 g, a yield of 92%;

References:

Wang Yanping;Yang Yi;Zhang Xiaoling;Zhou Qinghe;Xu Congying CN108218833, 2018, A Location in patent:Paragraph 0043; 0044; 0057; 0058; 0063; 0071; 0072

2650-64-8 Synthesis