3-(4-FLUORO-BENZYLOXY)-BENZALDEHYDE synthesis
- Product Name:3-(4-FLUORO-BENZYLOXY)-BENZALDEHYDE
- CAS Number:168084-96-6
- Molecular formula:C14H11FO2
- Molecular Weight:230.23
Yield:168084-96-6 91%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 80; for 3 h;
Steps:
7.1 (1) 3 - (4 - fluorobenzyloxy) benzaldehyde preparation
The 3 - hydroxybenzaldehyde (1.0 g, 8.2 mmol) dissolved in 15 ml DMF in, add 4 - [...] (1.7 g, 9.0 mmol), potassium carbonate (1.35 g, 9.8 mmol), 80 °C reaction 3 hours, adding 15 ml distilled water, extracted with ethyl acetate twice (2 × 20 ml), then saturated sodium chloride solution for washing 1 time, dried with anhydrous sodium sulfate. Concentrated, column chromatography, eluting agent is petroleum ether: ethyl acetate=3:1, to obtain white solid 1.72 g, yield 91%
References:
CN107151220,2017,A Location in patent:Paragraph 0161; 0162; 0163; 0164; 0165
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