ChemicalBook CAS DataBase List 3,5-DibroMo-1-Methylpyrazin-2(1H)-one

3,5-DibroMo-1-Methylpyrazin-2(1H)-one synthesis

5synthesis methods

Product Name:3,5-DibroMo-1-Methylpyrazin-2(1H)-one
CAS Number:87486-34-8
Molecular formula:C5H4Br2N2O
Molecular Weight:267.91

15219-34-8 Synthesis

15219-34-8
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25808-30-4
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87486-34-8
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$19.00/250mg

Yield: 92%

Reaction Conditions:

in dichloromethane;N,N-dimethyl-formamide at 0 - 55; for 16 h;

Steps:

1 Synthesis of 3,5-dibromo-l-meth lpyrazin-2(lH)-one
To a suspension of methylamino acetonitrile hydrochloride (20 g, 142.0 mmol) in DCM (1300 ml), was added oxalyl bromide (54 ml, 188.67 mmol) followed by slow addition of DMF (1.5 ml) at 0°C. The reaction mixture was stirred at 55°C for 16 h. DCM was concentrated under reduced pressure, the residue obtained was purified by column chromatography by eluting with 2% MeOH/CH₂Cl₂ to afford the desired compound as a pale yellow solid (34 g, 92 %); *H NMR (400MHz, DMSO-dg) δ 8.1 (s, 1H), 3.4 (s, 3H). LC-MS: 268.9 (M+l)⁺.

References:

AURIGENE DISCOVERY TECHNOLOGIES LIMITED;BORUAH, Anima;HOSAHALLI, Subramanya;PANIGRAHI, Sunil Kumar WO2014/108820, 2014, A1 Location in patent:Page/Page column 27

15219-34-8 Synthesis

15219-34-8
71 suppliers
$100.00/25g