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Methylamine

Organic Chemicals Poisoning Uses Production method

CAS No. 74-89-5
Chemical Name: Methylamine
Synonyms: CH3NH2;MMA-40;MMA-50;AMINE C1;Methylamin;Metilamine;Methanamine;Carbinamine;Aminomethan;Metyloamina
CBNumber: CB4387750
Molecular Formula: CH5N
Formula Weight: 31.06
MOL File: 74-89-5.mol
Methylamine Property
Melting point : -93 °C(lit.)
Boiling point : -6.3 °C(lit.)
density : 0.785 g/mL at 25 °C
vapor density : 1.08 (20 °C, vs air)
vapor pressure : 27 psi ( 20 °C)
refractive index : n20/D 1.371
Fp : 61 °F
storage temp. : Flammables area
pka: 10.63(at 25℃)
explosive limit: 4.9-20.8%
Water Solubility : Miscible with water, ethanol, benzene, acetone and ether.
Merck : 14,6014
BRN : 741851
Stability:: Stable. Highly flammable. Note wide explosion limits. Incompatible with oxidizing agents, acids, alkalies, alkaline earth metals, copper and its alloys, zinc and its alloys.
CAS DataBase Reference: 74-89-5(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : F+,Xn,C,F,T
Risk Statements : 12-20-37/38-41-34-20/22-11-39/23/24/25-36/37/38-23/24/25-40-19
Safety Statements : 7-16-26-36/37-45-29-36/37/39-3/7-3-39-33
RIDADR : UN 3286 3/PG 2
WGK Germany : 2
RTECS : PF6300000
F : 4.5-31
TSCA : Yes
HazardClass : 3
PackingGroup : II
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H220 Extremely flammable gas Flammable gases Category 1 Danger P210, P377, P381, P403
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H280 Contains gas under pressure; may explode if heated Gases under pressure Compressed gas
Liquefied gas
Dissolved gas
Warning P410+P403
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H333 May be harmful if inhaled Acute toxicity,inhalation Category 5 P304+P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P377 Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.
P410+P403 Protect from sunlight. Store in a well-ventilated place.

Methylamine Chemical Properties,Usage,Production

Organic Chemicals
Methylamine, also known as amino methane, is an important kind of organic chemical raw materials and intermediates and is a flammable colorless gas at normal temperature and pressure. Upon being liquefied or compressed at high concentrations, it has a strong odor of ammonia. It has fishy odor at very low concentrations. It is easily soluble in water and soluble in alcohol and ether. It is flammable and can form explosive mixtures with air with the explosive limit being 4.3% to 21%. It has weak alkalinity with the alkaline being stronger than ammonia. It can interact with inorganic acid to form water-soluble salts. It is obtained through the reaction between methanol and ammonia at high pressure and high temperature in the action of catalyst. Alternatively, it can be obtained through the reaction between formaldehyde and ammonium chloride upon being heated to 300 ℃ in the presence of zinc chloride. Methylamine can be used to make pesticides, pharmaceuticals, rubber vulcanization accelerator, dyes, explosives, leather, petroleum, surfactants, and ion exchange resin, paint strippers, and coatings as well as additives. It is an important raw material for the manufacturing of pesticide dimethoate, carbaryl, and chlordimeform. The inhalation toxicity of methylamine belongs to low toxicity category. The maximum allowable air concentration is 5mg/m3 (0.4ppm). It is corrosive and can cause irritation of the eyes, skin and mucous membranes. In case of fire, high heating temperature, it can cause risk of fire with cylinders and accessories damage being capable of causing an explosion.
Poisoning
Methylamine belongs to moderate-poisoning drug with a strong irritant and corrosive property. During the process of production and in transit, when there is leakage occurring due to accident, it can cause acute poisoning of contacted people.
This product can be subject to inhalation in its gaseous state from the respiratory tract. Its solution can be absorbed through the skin. Its salt can cause poisoning upon mistakenly oral administration. This product has a strong stimulating effect on eye; upper respiratory tract, skin and mucous membranes. Inhalation of it at high concentrations can cause damage to the lungs with people in severe cases getting pulmonary edema and respiratory distress syndrome, finally leading to death. However, it has been no yet reported of cases of systemic poisoning around the world. Liquid methylamine has strong irritation and corrosion effect and can cause eye and skin chemical burning. In case of 40% aqueous methylamine being splashed into the eyes, the victims can get burning eyes, photophobia, lacrimation, conjunctival hyperemia, eyelid irritation, corneal edema and superficial ulcers with those symptoms being able to last 1 to 2 weeks. Long-term exposure to low concentrations of methylamine can cause dryness and discomfort of the eyes, nose, and throat.
[first-aid]
Upon skin contact, the victim should immediately remove the contaminated clothing, wash it thoroughly with a large amount of flowing water. For first-aid, the victim can apply 1 to 2% acetic acid, 0.5% citric acid to wash the skin, mucous membranes and mouth.
When the eyes are contaminated, they should raise the eyelid and wash the eyes with flowing clean water and saline for at least 15 minutes, followed by fluorescein staining. If there is corneal injury occurring, the victims should be invited to an ophthalmologist for treatment.
For patients inhaling nitric methylamine gas and getting poisoned, they should be rapidly transferred from the scene of fresh air and keep the airway open. For patients with breathing difficulties, they should be given oxygen. Patients of respiratory and cardiac arrest should be immediately subject to artificial respiration and sent to hospital immediately after treatment in a timely manner.
This information is edited by Xiongfeng Dai from Chemicalbook.
Uses
Methylamine is an important kind of fatty amines organic chemicals and is widely applied to pesticide production. It can be used in the synthesis of the N-methyl-chloroacetamide that is the intermediate of the organic phosphorus insecticide dimethoate and omethoate; synthesis of the intermediate of the monocrotophos, α-chloro acetoacetyl methylamine; synthesis of the intermediates of carbamate pesticide, carbamoyl chloride and methyl isocyanate; as well as the synthesis of other pesticides varieties such as formamidine, amitraz, and tribenuron, etc. In addition, it can also be used in medicine, rubber, dyes, leather industry and photosensitive materials.
Production method
There are a lot of ways for manufacturing of methylamine. But in industry, people mainly apply methanol amination.
CH3OH + NH3 → CH3NH2 + H2O
2CH3OH + NH3 → (CH3) 2NH + 2H2O
3CH3OH + NH3 → (CH3) 3N + 3H2O
It is obtained through the following process: methanol and ammonia is at a ratio of 1.5 to 4 and subject to continuous vapor phase catalytic amination at high temperature and high pressure with activated alumina as a catalyst to generate the mixture crude product of mono-, di-, trimethylamine. The crude mixture further goes through a series of distillation column for continuous pressure and distillation separation, have cooling for deamination, dehydration can yield respectively mono-, di-, trimethylamine products.
Chemical Properties
colourless gas (or solution in water or methanol)
Definition
ChEBI: The simplest of the methylamines, consisting of ammonia bearing a single methyl substituent.
General Description
A colorless gas or a liquid. Pungent fishy odor resembling odor of ammonia. The liquid boils at 20.3°F hence vaporizes rapidly when unconfined. Vapors are heavier than air and may collect in low-lying areas. Easily ignited under most conditions. Under prolonged exposure to intense heat the containers may rupture violently and rocket. Used for making pharmaceuticals, insecticides, paint removers, surfactants, rubber chemicals.
Air & Water Reactions
Highly flammable. Very soluble in water; the solutions are strongly basic and therefore corrosive. Liquid fumes in air.
Reactivity Profile
METHYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.
Health Hazard
VAPOR: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. LIQUID: Will burn skin and eyes.
Fire Hazard
FLAMMABLE. POISONOUS GASES MAY BE PRODUCED IN FIRE. Containers may explode in fire. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Toxic nitrogen oxides may be formed. Vapors are heavier than air and may travel considerable distance to a source of ignition and flash back.
Methylamine Preparation Products And Raw materials
Raw materials
o/p-Toluenesulfonamide TRIMETHYLAMINE HYDROCHLORIDE
Preparation Products
N-Methyl-4-pyridinamine 3-Hydrazinyl-N-methylpropanamide N-Cyano-N'-methyl-ethanimidamide sodium oleyl sarcosinate additive AC1210 fluorescent whitening agent AT didodecyl dimethyl ammoniumm 2-METHOXYPHENAMINE HCL 1-Methyl-3-phenyl-2-thiourea BIFEMELANE N,N-DIMETHYL-4-[(METHYLAMINO)METHYL]ANILINE Noncyanide zinc plating additive DE 3,4,5-TRIMETHACARB METHYL-(2-TRIFLUOROMETHYL-BENZYL)-AMINE CHLOROMETHYLACETAMIDE 4-Chloro-N-methylaniline (4-FLUORO-BENZYL)-METHYL-AMINE N-Methylpentylamine (3-FLUOROBENZYL)METHYLAMINE Disperse Red 9 2-CHLORO-N-METHYLACETOACETAMIDE 5-Chloro-2-methyl-3(2H)-isothiazolone with 2-methyl-3(2H)-isothiazolone 1,3-Dimethylurea Zolpidem ROTENONE 2-AMINO-4-METHYLAMINO-6-ETHOXY-1,3,5-TRIAZINE (1H-IMIDAZOL-2-YLMETHYL)-METHYL-AMINE 3-METHOXY-N-METHYLBENZYLAMINE 97 Bonnecor 2-Hydrazinyl-N-methylacetamide 2-Methoxy-N-methylbenzylamine hydrochloride ,97% (2-FLUOROBENZYL)METHYLAMINE N-(4-Methoxybenzyl)-N-methylamine POLY DIMETHYL DIALLYL AMMONIUM CHLORIDE Rilmazafone 3-CHLORO-N-METHYLBENZYLAMINE N-METHYLURETHANE Methimazole METHYL-PYRIDIN-2-YLMETHYL-AMINE 1-Methyl-3-pyrrolidinol
Methylamine Suppliers      Global( 193)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Secco work (Beijing) chemical technology co., LTD 010-69755668;
010-69755668 1139670422@qq.com China 3549 54
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30314 84
Quzhou Prince Biological Technology Co. Ltd. 0570-6581212,13567026655
0570-6259500 jeryy@cnprincebio.com China 39 58
Jonny pharmaceutical co.,ltd Ship products from Netherlands. Pls contact for PGP or ECC ID to talk!
Wickr: chemjonny, Pls contact for PGP or ECC ID to talk! chemjonny@openmailbox.org China 195 55
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44197 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 25125 65
Nanjing Spcscientific Technology Co., Ltd. 18994006456
sales1@spcscientific.com China 192 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40403 62
Beijing dtftchem Technology Co., Ltd. 13651141086; 86(10)60275028、60275820
86 (10) 60270825 dtftchem@sina.com China 3437 62
 
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