3-CHLORO-1-(2,3-DIHYDRO-1H-INDOL-1-YL)PROPAN-1-ONE synthesis

Yield:64140-62-1 100%

Reaction Conditions:

in acetone at 70; for 3 h;

Steps:

16

To a solution of 2,3-dihydro-1H-indole (4.0 g, 0.034 mol) in acetone (100 mL) was added 3-chloro- propionyl chloride (4.7 g, 0.037 mol). After heating the mixture at 70⁰C for 3 h, the solvent was removed in vacuo. The resulting residue was dissolved in CH₂CI₂ and washed with water and with brine. The organic layer was dried over Na₂SO₄, filtered, and concentrated to give the title compound as a brown solid (7.0 g, quantitative). ¹H NMR 400 MHz (CDCI₃) δ 8.22 (1 H, d), 7.20 (2H, m), 7.02 (1 H, t), 4.05 (2H, t), 3.92 (2H₁ 1), 3.20 (2H, t), 2.90 (2H, t).

References:

WO2008/15516,2008,A1 Location in patent:Page/Page column 36