3-(Chloromethyl)phenyl acetate synthesis

6synthesis methods

Product Name:3-(Chloromethyl)phenyl acetate
CAS Number:4530-44-3
Molecular formula:C9H9ClO2
Molecular Weight:184.62

122-46-3
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4530-44-3
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4530-45-4 Synthesis

4530-45-4
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Yield:-

Reaction Conditions:

with sulfuryl dichloride;2,2'-azobis(isobutyronitrile) in chloroform; for 3 h;Inert atmosphere;Reflux;

Steps:

1.2; 3.2

In a dry reaction flask, add 32 g of 3-methylphenylacetate and 1.5 g of azobisisobutyronitrile; replace with vacuum three times with nitrogen, add 160 ml of chloroform under nitrogen, stir and heat to reflux. 64 g of sulfonyl chloride and 0.8 g of azobisisobutyronitrile were added dropwise, and the mixture was added dropwise for 3 hours or more. After the completion of the dropwise addition, the reaction was continued for 0.5 h or more, passed the GC test, and evaporated to dryness under reduced pressure to obtain a chlorinated liquid.

References:

CN109053443,2018,A Location in patent:Paragraph 0025; 0034; 0040-0043; 0082; 0088-0091