3-hydroxynonyl acetate synthesis
- Product Name:3-hydroxynonyl acetate
- CAS Number:60826-15-5
- Molecular formula:C11H22O2
- Molecular Weight:186.29
624-51-1
86 suppliers
$56.00/25mL
141-78-6
601 suppliers
$24.69/250ml
60826-15-5
9 suppliers
inquiry
Yield:60826-15-5 89%
Reaction Conditions:
with iodine for 3 h;Reflux;chemoselective reaction;
Steps:
2. Typical procedure for alcohol acetylation
General procedure: To a solution of benzyl alcohol (0.108 g, 1 mmol) in ethyl acetate (2 mL), iodine (0.1 mmol)was added and the mixture was heated at reflux for 2 h. When the reaction was complete(monitored by TLC), it was cooled and a saturated sodium thiosulfate solution (5 mL) was added. The reaction mixture was extracted with ethyl acetate (3x10 mL). The combined organiclayers were washed with brine, dried over anhydrous sodium sulphate and concentrated invacuo. The crude was then purified by column chromatography to give 1a in 97% yield (145mg, 0.97 mmol).
References:
Basumatary, Grace;Bez, Ghanashyam [Tetrahedron Letters,2017,vol. 58,# 45,p. 4312 - 4315] Location in patent:supporting information
