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Ethyl acetate

Introduction Solubility in water Purification and water removal methods Uses Production Category Toxicity grading Acute oral toxicity Irritation data Hazardous characteristics of explosive Flammability and hazard characteristics Storage characteristics Extinguishing agent Professional standards
Ethyl acetate
Ethyl acetate
CAS No.
141-78-6
Chemical Name:
Ethyl acetate
Synonyms
ETOH;Etile;EtOAc;SPIRIT;Ethyle;ALCOHOL;Vinasse;Acetidin;FEMA 2414;ai3-00404
CBNumber:
CB7255315
Molecular Formula:
C4H8O2
Formula Weight:
88.11
MOL File:
141-78-6.mol

Ethyl acetate Properties

Melting point:
−84 °C(lit.)
Boiling point:
76.5-77.5 °C(lit.)
Density 
0.902 g/mL at 25 °C(lit.)
vapor density 
3 (20 °C, vs air)
vapor pressure 
73 mm Hg ( 20 °C)
refractive index 
n20/D 1.3720(lit.)
FEMA 
2414 | ETHYL ACETATE
Flash point:
26 °F
storage temp. 
2-8°C
solubility 
Miscible with ethanol, acetone, diethyl ether and benzene.
pka
16-18(at 25℃)
form 
Liquid
color 
APHA: ≤10
Relative polarity
0.228
explosive limit
2.2-11.5%, 38°F
Water Solubility 
80 g/L (20 ºC)
Merck 
14,3757
BRN 
506104
Stability:
Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
InChIKey
XEKOWRVHYACXOJ-UHFFFAOYSA-N
CAS DataBase Reference
141-78-6(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl acetate(141-78-6)
EPA Substance Registry System
Acetic acid ethyl ester(141-78-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,Xi,Xn,T
Risk Statements  11-36-66-67-20/21/22-10-39/23/24/25-23/24/25-68/20/21/22
Safety Statements  16-26-33-36/37-45-7-25
RIDADR  UN 1173 3/PG 2
WGK Germany  1
RTECS  AH5425000
1
TSCA  Yes
HazardClass  3
PackingGroup  II
Hazardous Substances Data 141-78-6(Hazardous Substances Data)
Toxicity LD50 orally in rats: 11.3 ml/kg (Smyth)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Ethyl acetate price More Price(110)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1.00789 Ethyl Acetate 141-78-6 1EA $60.5 2017-11-08 Buy
Sigma-Aldrich 1.00789 Ethyl Acetate 141-78-6 2EA $126 2017-11-08 Buy
TCI Chemical A0030 Ethyl Acetate [for Spectrophotometry] >99.5%(GC) 141-78-6 250mL $43 2017-11-08 Buy
Alfa Aesar 22912 Ethyl acetate, HPLC Grade, 99.5+% 141-78-6 1L $54.4 2017-11-08 Buy
Alfa Aesar 22912 Ethyl acetate, HPLC Grade, 99.5+% 141-78-6 *4x1L $189 2017-11-08 Buy

Ethyl acetate Chemical Properties,Uses,Production

Introduction

Ethyl Acetate is an organic ester compound with a molecular formula of C4H8O2 (commonly abbreviated as EtOAc or EA), appears as a colorless liquid. It is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters), which make it a common solvent for cleaning, paint removal and coatings.
Ethyl acetate is found in alcoholic beverages, cereal crops, radishes, fruit juices, beer, wine, spirits etc. It has a fruity characteristic odor that is commonly recognized in glues, nail polish remover, decaffeinating tea and coffee, and cigarettes. Due to its agreeable aroma and low cost, this chemical is commonly used and manufactured in large scale in the world, as over 1 million tons annually.

Solubility in water

8.3 g/100 mL (20 °C)

Purification and water removal methods

Ethyl acetate generally has a content of 95% to 98% containing a small amount of water, ethanol and acetic acid. It can be further purified as following: add 100mL of acetic anhydride into 1000mL of ethyl acetate; add 10 drops of concentrated sulfuric acid, heat and reflux for 4h to remove impurities such as ethanol and water, and then further subject to distillation. Distillate is oscillated by 20~30g of anhydrous potassium carbonate and further subject to re-distillation. The product has a boiling point of 77 °C and purity being over 99%.

Uses

Industry Applications Role/Benefit
Flavor and essence Food flavor Used largely to prepare bananas, pears, peaches, pineapple and grape scent food flavors, etc
Alcoholic essence Used slightly as fragrance volatile
Perfume essence Used slightly as fragrance volatile
Chemical manufacture Production of acetamide, acetyl acetate, methyl heptanone, etc Organic chemical raw materials
Production of organic acid Extracting agent
Laboratory Dilution and extraction Supply excellent dissolving capacity
Chromatographic analysis Standard material
Column chromatography and extractions Main component of mobile phase
Reaction solvent Be prone to hydrolysis and transesterification
Chemical analysis Thermometer calibration for sugar separation  Standard material
Determination of bismuth, boron, gold, molybdenum, platinum and thallium Solvent
Entomology Insect collecting and study Used as effective asphyxiant to kill the collected insect quickly without destroying it
Textile industry Cleaning agent Supply excellent dissolving capacity
Printing Flexographic and rotogravure printing Dissolve the resin, control the viscosity and modify the drying rate
Electronics industry Viscosity reducer Reduce the viscosity of resins used in photoresist formulations
Paint manufacture Solvent Dissolve and dilute the paints
Health & personal care products The formulation of nail polish, nail polish removers and other manicuring products Supply excellent dissolving capacity
Pharmaceutical Medicine manufacturing Extraction agent; intermediate
Cosmetics Aroma enhancer In perfume to enhance aroma
Others Tanning extracts Used for desulfurization of tanning, cigarette materials, oil field drilling, metal flotation, descaling, etc
Production of adhesive Solvent
Extract many compounds (phosphorus, cobalt, tungsten, arsenic) from aqueous solution Extracting agent

Production

Industrial production of ethyl acetate is mainly classified into three processes.

The first one is a classical Fischer esterification process of ethanol with acetic acid in presence of acid catalyst. This process needs acid catalyst2 such as sulphuric acid, hydrochloride acid, ptoluene sulfonic acid etc. This mixture converts to the ester in about 65% yield at room temperature. 
CH3CH2OH + CH3COOH ↔ CH3COOC2H5 + H2O
The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.

The second one is Tishchenko Reaction of acetaldehyde using aluminium triethoxide as a catalyst. In Germany and Japan, most ethyl acetate is produced via the Tishchenko process. 
2 CH3CHO → CH3COOC2H5
This method has been proposed by two different routes; (i) dehydrogenative process, which uses copper or palladium based catalyst and (ii) the oxidative one, which employs, PdO supported catalysts.

The third one, which has been recently commercialized, is addition of acetic acid to ethylene using clay and heteroploy acid7 as a catalyst. 
CH2= CH2 + CH3COOH → CH3COOC2H5 
The processes, however, have some disadvantages; both the conventional esterification and addition of acetic acid to ethylene need stock tanks and apparatus for several feed stocks. Moreover, they use acetic acid that causes apparatus corrosion. Although Teshchenko Reaction uses only one feed and it is a non-corrosive material, it is difficult to handle acetaldehyde because is not available outside of petrochemical industrial area.
In such circumstances, an improved process of ethyl acetate production is strongly desired.

Category

Flammable liquid

Toxicity grading

poisoning

Uses

Pharmaceutic aid (flavor); artificial fruit essences; solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacture of smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc.

Acute oral toxicity

rat LD50: 5620 mg/kg; Oral-Mouse LD50: 4100 mg/kg

Irritation data

eye-people 400 PPM

Hazardous characteristics of explosive

explosive when mixed with air

Flammability and hazard characteristics

it is flammable in case of fire, high temperature, and oxidant with burning causing irritated smoke

Storage characteristics

Treasury: ventilation, low-temperature and dry; store it separately from oxidants

Extinguishing agent

dry powder, dry sand, carbon dioxide, foam, and 1211 fire extinguishing agent

Professional standards

TWA 1400 mg/m³; STEL 2000 mg/m³

Air & Water Reactions

Highly flammable. Slightly soluble in water. Ethyl acetate is slowly hydrolyzed by moisture.

Reactivity Profile

Ethyl acetate is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. Ethyl acetate may ignite or explode with lithium aluminum hydride. Ethyl acetate may also ignite with potassium tert-butoxide. Ethyl acetate is incompatible with nitrates, strong alkalis and strong acids. Ethyl acetate will attack some forms of plastics, rubber and coatings. Ethyl acetate is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as Ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).

Health Hazard

Headache, irritation of respiratory passages and eyes, dizziness and nausea, weakness, loss of consciousness.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Ethyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products


Ethyl acetate Suppliers

Global( 461)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 500 55
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 322 50
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20808 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1374 55
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ATK CHEMICAL COMPANY LIMITED
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86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1410 55
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Yancheng Green Chemicals Co.,Ltd
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View Lastest Price from Ethyl acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-03 Ethyl acetate
141-78-6
US $20.00 / KG 1KG 97% 1000KG
2018-08-03 Ethyl acetate
141-78-6
US $20.00 / KG 1KG 97% 1000KG
2018-05-23 ethyl acetate
141-78-6
US $10.00 / KG 1000KG 99% 1000 ton Meihua Biological Technology Co.,Ltd

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