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3-Methoxypyridine-4-carboxylic acid methyl ester synthesis

8synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 62 percent / 10 percent hydrochloric acid / 5 h / 90 °C
2: 55 percent / hydrogen chloride / methanol / 2 h / Ambient temperature
3: 30 percent / isopentyl nitrite / dimethylformamide / 65 °C

References:

Tamura, Yasumitsu;Chen, Ling Ching;Fujita, Masanobu;Kita, Yasuyuki [Chemical and pharmaceutical bulletin,1982,vol. 30,# 4,p. 1257 - 1262]