tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate synthesis
- Product Name:tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
- CAS Number:365996-06-1
- Molecular formula:C11H15BrN2O2S
- Molecular Weight:319.22
540-80-7
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![TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE](/CAS/GIF/365996-05-0.gif)
365996-05-0
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$54.00/1 / G
365996-06-1
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$56.00/250mg
Yield: 44%
Reaction Conditions:
with copper(ll) bromide in dichloromethane at 0; for 3 h;
Steps:
29.3 tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
To a stuffing solution of tert-butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine- 5(4H)-carboxylate (2.0 g, 7.84 mmol) in DCM (30 mL) was added tert-butyl nitrite (1.24 g, 12 mmol) and CuBr2 (1.78 g, 8 mmol). The solution was stirred at 0 °C for 3h. Once LCMS showed the reaction to be complete, solvents were then evaporated and the residue was purified with column separation to afford desired product as white solid (1.1 g, yield: 44%);LCMS: 318.9/320.9 (M+1).
References:
EPIZYME, INC.;DUNCAN, Kenneth, W.;CHESWORTH, Richard;MUNCHHOF, Michael, John;SHAPIRO, Gideon WO2015/200677, 2015, A2 Location in patent:Paragraph 00647; 00648
365996-05-0
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365996-06-1
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$56.00/250mg
7789-45-9
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365996-05-0
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$54.00/1 / G
365996-06-1
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79099-07-3
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365996-06-1
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$56.00/250mg
188869-05-8
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365996-06-1
131 suppliers
$56.00/250mg