ChemicalBook CAS DataBase List 4,4'-DI-TERT-BUTYLBIPHENYL

4,4'-DI-TERT-BUTYLBIPHENYL synthesis

9synthesis methods

Product Name:4,4'-DI-TERT-BUTYLBIPHENYL
CAS Number:1625-91-8
Molecular formula:C20H26
Molecular Weight:266.42

92-52-4 Synthesis

92-52-4
380 suppliers
$9.00/5g

507-20-0 Synthesis

507-20-0
354 suppliers
$14.00/25mL

1625-91-8
170 suppliers
$10.00/5g

Yield:1625-91-8 100%

Reaction Conditions:

iron(III) chloride in dichloromethane at 20;

Steps:

23

To a stirred solution of biphenyl (15.4 g, 100 mmol) and anhydrous ferric chloride (80 mg) in dichlorometfaaiie (100ml) at room temperature was added slowly tert-butyl chloride (23.2 .ml, 21(5 mmol). The reaction was stirred overnight. The product was washed with water and extracted with hexane (100 ml) 3 times. The combined organic phase was washed with brine, dried over anhydrous MgSO₄ and concentrated in vacuo and gave 26.6 g of Compound S (yield 100%). ¹H NMR (400 MHz, chloroform-d): δ, ppm 7.542 (d, 4 H), 7.444 (d, 4 H), 1.365 (s, 18 H).

References:

WO2006/93466,2006,A1 Location in patent:Page/Page column 37; Sheet 13

35779-04-5 Synthesis