ChemicalBook CAS DataBase List 4,4'-DIMETHOXYDIPHENYLAMINE

4,4'-DIMETHOXYDIPHENYLAMINE synthesis

15synthesis methods

Product Name:4,4'-DIMETHOXYDIPHENYLAMINE
CAS Number:101-70-2
Molecular formula:C14H15NO2
Molecular Weight:229.27

696-62-8
349 suppliers
$5.00/1g

104-94-9 Synthesis

104-94-9
471 suppliers
$9.00/1g

101-70-2
215 suppliers
$32.00/1g

Yield:101-70-2 99%

Reaction Conditions:

with sodium t-butanolate;1,1'-bis-(diphenylphosphino)ferrocene;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ in tetrahydrofuran at 100; for 3 h;

Steps:

4-Methoxyaniline (308 mg, 2.5 mmol), 4- methoxyiodobenzene (585 mg, 2.5 mmol), DPPF (166 mg, 0.3 mmol), (DPPF)PdCI₂-CH₂CI₂ (82 mg, 0.01 mmol), sodium tert-butoxide (240 mg, 2.5 mmol) and THF (5 mL) was mixed in a sealed vial and stirred at 100 °C for 3 h in an oilbath. After cooling to room temperature DCM and water was added to the reaction mixture and the organic phase was passed through at phase separation filter and concentrated. The crude product was purified on SiO₂ column (100% DCM) to give the product (573 mg, 99%). LC/MS (an20p5): Rt 2.3 min, m/z 230 [M+H]

References:

WO2007/62797,2007,A1 Location in patent:Page/Page column 26

5720-07-0 Synthesis