4-(4-NITRO-BENZOYL)-BENZOIC ACID synthesis
- Product Name:4-(4-NITRO-BENZOYL)-BENZOIC ACID
- CAS Number:7377-13-1
- Molecular formula:C14H9NO5
- Molecular Weight:271.23
5350-47-0
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7377-13-1
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Yield:7377-13-1 85%
Reaction Conditions:
with chromium(VI) oxide;sulfuric acid in acetic acid at 0 - 20;
Steps:
4-(4-Nitrobenzoyl)benzoic acid (7)
To an ice-cooled mixture of 6 (20.00 g, 0.08 mol) in glacial acetic acid (150 mL) was added sulfuric acid (28 mL) slowly to keep the temperature below 5 °C. Chromium oxide (28.00 g, 0.28 mol) was added in small portions at such a rate that the temperature did not exceed 10 °C. The reaction solution was stirred at room temperature overnight, then ice water (20 mL) was added. The precipitated solid was filtered, washed with water and dried to afford 7 22.0 g (85%) of a white powder. mp 254-256 °C.
References:
Zhang, Liying;Zhang, Yingxia;Dong, Jizhe;Liu, Jun;Zhang, Luyong;Sun, Hongbin [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 2,p. 1036 - 1039] Location in patent:supporting information; experimental part
108-88-3
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$14.00/100ml
7377-13-1
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122-04-3
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$15.00/1g
7377-13-1
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62-23-7
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$14.00/25g
7377-13-1
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