ChemicalBook CAS DataBase List 4-ACETOXYACETOPHENONE

4-ACETOXYACETOPHENONE synthesis

12synthesis methods

Product Name:4-ACETOXYACETOPHENONE
CAS Number:13031-43-1
Molecular formula:C10H10O3
Molecular Weight:178.18

Preparation by acetylation of 4-hydroxyacetophenone with acetic anhydride,
? in the presence of aluminium triflate for 10 min at r.t. (98%);
? in the presence of sodium acetate.

108-05-4
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$4.00/1000g

99-93-4 Synthesis

99-93-4
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13031-43-1
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$9.00/1g

Yield: 98%

Reaction Conditions:

with sodium carbonate in acetonitrile at 120; for 24 h;Schlenk technique;

Steps:

General Procedure for the Synthesis of Aryl Carboxylates
General procedure: A mixture of phenol 1 (0.50 mmol), Na2CO3 (10.6 mg, 0.10mmol, 20 mol%), and alkenyl carboxylate (2.0 mmol, 4.0 equiv)in MeCN (3 mL) was added to a Schlenk flask (25 mL) and stirredat r.t. The mixture was stirred at 120 °C until the reaction wasfinished. Then, the solvent was evaporated under reduced pressureand the residue was purified by column chromatography(petroleum ether/ethyl acetate 20:1 to 10:1) to afford theproduct 3.

References:

Zhou, Xiao-Yu;Chen, Xia [Synlett,2018,vol. 29,# 17,p. 2321 - 2325] Location in patent:supporting information