4-BROMO-2-FLUOROBENZALDEHYDE DIMETHYL ACETAL synthesis
- Product Name:4-BROMO-2-FLUOROBENZALDEHYDE DIMETHYL ACETAL
- CAS Number:439814-87-6
- Molecular formula:C9H10BrFO2
- Molecular Weight:249.08
67-56-1
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57848-46-1
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439814-87-6
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Yield:439814-87-6 99%
Reaction Conditions:
with hydrogenchloride at 20; for 2 h;
Steps:
1.1 Step 1 4-Bromo-l-(dimethoxymethyl)-2-fluorobenzene
Step 1 4-Bromo-l-(dimethoxymethyl)-2-fluorobenzene A solution of 4-bromo-2-fiuoro-benzaldehyde (5 g, 24.6 mmol) in a solution of 2 M methanolic HC1 (100 mL) was stirred at ambient temperature for 2 hours. The solution was then concentrated and dried under reduced pressure to give 4-bromo-l- (dimethoxymethyl)-2-fiuoro-benzene (6.1 g, 99% yield). 1 H NMR (400 MHz, CDC13) δ 7.52 - 7.39 (m, 1H), 7.33 - 7.27 (m, 1H), 7.27 - 7.20 (m, 1H), 5.54 (s, 1H), 3.36 (s, 6H).
References:
WO2013/92941,2013,A1 Location in patent:Page/Page column 39
497-19-8
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57848-46-1
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439814-87-6
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$351.00/1g
57848-46-1
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149-73-5
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439814-87-6
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1435-52-5
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439814-87-6
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