5-BROMO-2-(1H-IMIDAZOL-1-YL)PYRIMIDINE synthesis
- Product Name:5-BROMO-2-(1H-IMIDAZOL-1-YL)PYRIMIDINE
- CAS Number:883230-68-0
- Molecular formula:C7H5BrN4
- Molecular Weight:225.05
288-32-4
972 suppliers
$5.00/25g
62802-38-4
185 suppliers
$10.00/1g
883230-68-0
31 suppliers
$45.00/100mg
Yield:883230-68-0 95%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide at 70; for 24 h;Schlenk technique;
Steps:
Preparation of Substrates; General Procedure
General procedure: 5-Bromo-2-fluoropyridine (0.5 mmol), an N-heterocyclic amine (1.0 mmol) and K2CO3 (1.0 mmol) were added to a 25-mL Schlenk tube, followed by addition of DMSO (2 mL). The reaction mixture was heated to 70 °C for 24 h under air atmosphere. Then, the reaction mixture was added to brine (15 mL) and this mixture was extracted with CH2Cl2 (3 × 15 mL). The combined extracts were concentrated under reduced pressure and the product was isolated by flash chromatography on a silica gel (200-300 mesh) column.
References:
Tao, Sheng;Ji, Enhui;Shi, Lei;Liu, Ning;Xu, Liang;Dai, Bin [Synthesis,2017,vol. 49,# 23,p. 5120 - 5130]
288-32-4
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$5.00/25g
32779-36-5
616 suppliers
$5.00/5g
883230-68-0
31 suppliers
$45.00/100mg
288-32-4
972 suppliers
$5.00/25g
183438-24-6
386 suppliers
$6.00/1g
883230-68-0
31 suppliers
$45.00/100mg