5-(BROMOMETHYL)-2-METHOXYPYRIDINE synthesis
- Product Name:5-(BROMOMETHYL)-2-METHOXYPYRIDINE
- CAS Number:128632-03-1
- Molecular formula:C7H8BrNO
- Molecular Weight:202.05
58584-63-7
91 suppliers
$60.00/5g
128632-03-1
43 suppliers
$71.00/100mg
Yield:128632-03-1 63%
Reaction Conditions:
with phosphorus tribromide in dichloromethane at 0 - 20; for 2 h;
Steps:
1 Step 1
To a stirred solution of (6-methoxypyridin-3-yl)methanol (0.60 g, 4.316 mmol, 1.0 eq) in DCM (20 mL), was added PBr3 (0.50 mL, 5.179 mmol, 1.2 eq) was added at 0° C. and the reaction was then stirred at RT for 2 h. After completion of the reaction (monitored by TLC, TLC system 5% MeOH in DCM, Rf-0.3), the reaction was quenched with sat. NaHCO3 solution (50 mL), extracted with DCM (3×50 mL), dried over Na2SO4 and concentrated to get 5-(bromomethyl)-2-methoxypyridine (0.55 g, 63%).
References:
Gruenenthal GmbH;JAKOB, Florian;ALEN, Jo;KRÜGER, Sebastian;SCHADE, Markus;FRIEBE, Daniela;HENNEN, Stephanie US2019/185455, 2019, A1 Location in patent:Paragraph 0354-0355
26218-80-4
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$7.00/1g
128632-03-1
43 suppliers
$71.00/100mg
5326-23-8
547 suppliers
$5.00/1g
128632-03-1
43 suppliers
$71.00/100mg