ChemicalBook CAS DataBase List 5-FLUORO-1,3-BENZOXAZOL-2(3H)-ONE

5-FLUORO-1,3-BENZOXAZOL-2(3H)-ONE synthesis

7synthesis methods

Product Name:5-FLUORO-1,3-BENZOXAZOL-2(3H)-ONE
CAS Number:13451-79-1
Molecular formula:C7H4FNO2
Molecular Weight:153.11

399-97-3 Synthesis

399-97-3
222 suppliers
$8.00/1g

530-62-1 Synthesis

530-62-1
916 suppliers
$6.00/25g

13451-79-1
51 suppliers
$12.00/250mg

Yield:13451-79-1 90%

Reaction Conditions:

in N,N-dimethyl-formamide at 80; for 5 h;Inert atmosphere;

Steps:

4.3 General preparation of intermediates 4

General procedure: The intermediates 4 were prepared as previously described [36] with some modification. Under the atmosphere of nitrogen, starting material aminophenol (1 equiv.) and N,N′-Carbonyldiimidazole (CDI) (1.2 equiv.) were mixed in DMF and stirred 80°C for 5h. The reaction mixture was allowed to cool to room temperature and the water was added to quench the reaction. The mixture was and extracted with ethyl acetate to afford the crude product that was purified by flash column chromatography on silica gel to yield 4a-d.

References:

Zou, Yi;Wang, Yan;Wang, Fang;Luo, Minghao;Li, Yuezhen;Liu, Wen;Huang, Zhangjian;Zhang, Yihua;Guo, Wenjie;Xu, Qiang;Lai, Yisheng [European Journal of Medicinal Chemistry,2017,vol. 138,p. 199 - 211]

394-32-1 Synthesis