ChemicalBook CAS DataBase List 8-Hydroxyquinoline-N-oxide

8-Hydroxyquinoline-N-oxide synthesis

5synthesis methods

Product Name:8-Hydroxyquinoline-N-oxide
CAS Number:1127-45-3
Molecular formula:C9H7NO2
Molecular Weight:161.16

8-hydroxyquinoline-N-oxide was synthesized from 8-hydroxyquinoline. A stirred solution of 8-hydroxyquinoline (25.00 g, 172.2 mmol) in 550 ml of CHCl₃ was cooled to 0° C., and 3 -chloroperoxybenzoic acid (40.00 g, 80% Tech. grade *0.231 mmol=0.185 mmol) was added slowly over 3 minutes. The solution was kept at 0° C. and stirred for 3 hours. During this period, the 3-chlorobenzoic acid byproduct precipitated. The 3-chlorobenzoic acid was removed by filtration and the orange filtrate was concentrated to dryness and the remaining solid was triturated with 2% NH40 H (2*200 ml). The solid was isolated on a frit and washed with H₂O.
synthesis of 8-hydroxyquinoline-N-oxide.png

synthesis of 8-hydroxyquinoline-N-oxide.png

148-24-3 Synthesis

148-24-3
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64741-01-1
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1127-45-3
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Yield:-

Reaction Conditions:

in chloroform;

Steps:

1 8-Hydroxyquinoline-N-Oxide

EXAMPLE 1 8-Hydroxyquinoline-N-Oxide In this example, 8-hydroxyquinoline-N-oxide was produced from 8-hydroxyquinoline. A stirred solution of 8-hydroxyquinoline (25.00 g, 172.2 mmol) in 550 ml of CHCl₃ was cooled to 0° C., and 3 -chloroperoxybenzoic acid (40.00 g, 80% Tech. grade *0.231 mmol=0.185 mmol) was added slowly over 3 minutes. The solution was kept at 0° C. and stirred for 3 hours. During this period, the 3-chlorobenzoic acid byproduct precipitated. The 3-chlorobenzoic acid was removed by filtration and the orange filtrate was concentrated to dryness and the remaining solid was triturated with 2% NH₄₀ H (2*200 ml). The solid was isolated on a frit and washed with H₂ O.

References:

US5021567,1991,A

148-24-3 Synthesis

148-24-3
805 suppliers
$5.00/25g

1127-45-3
214 suppliers
$6.00/1g

References