ChemicalBook CAS DataBase List Benzophenone

Benzophenone synthesis

15synthesis methods

Product Name:Benzophenone
CAS Number:119-61-9
Molecular formula:C13H10O
Molecular Weight:182.22

Benzophenone is commercially synthesized by the atmospheric oxidation of diphenylmethane using a catalyst of copper naphthenate. Alternatively, it can be produced by a Friedel–Crafts acylation of benzene using either benzoyl chloride or phosgene in the presence of aluminum chloride .

100-47-0
358 suppliers
$14.14/25gm:

98-80-6 Synthesis

98-80-6
694 suppliers
$5.00/5g

119-61-9
752 suppliers
$5.00/10g

Yield:119-61-9 99%

Reaction Conditions:

with trifluorormethanesulfonic acid;palladium diacetate;2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine in water at 60; for 3.5 h;

Steps:

General procedure for addition of arylboronic acids to nitrile

General procedure: To a mixture of arylboronic acid (1.2 mmol), nitrile (1.0 mmol), Pd(OAc)2 (4 mol%)and L1 (4 mol%), H2O (1.2 mL) and triflic acid (0.4 mL) were added and stirred at 60 °Cunder air for desired time (TLC monitoring). Then the reaction mixture was neutralized withsaturated NaHCO3 solution and extracted with ether. The combined ether solution waswashed with brine, dried by Na2SO4 and concentrated. The residue was purified by flashcolumn chromatography on silica gel using petroleum ether/cetone or petroleum ether/DCMas eluent to give the desired product.

References:

Das, Tuluma;Chakraborty, Amarnath;Sarkar, Amitabha [Tetrahedron Letters,2014,vol. 55,# 52,p. 7198 - 7202] Location in patent:supporting information

201230-82-2 Synthesis