Btk inhibitor 1 (R enantioMer hydrochloride) synthesis
- Product Name:Btk inhibitor 1 (R enantioMer hydrochloride)
- CAS Number:1553977-42-6
- Molecular formula:C22H23ClN6O
- Molecular Weight:422.9106
![1-Piperidinecarboxylic acid, 3-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-, 1,1-diMethylethyl ester, (3R)-](/CAS/20150408/GIF/1022150-11-3.gif)
1022150-11-3
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$14.00/100mg
1553977-42-6
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Yield:1553977-42-6 98%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;methanol;lithium hydroxide monohydrate;ethyl acetate at 20;
References:
B?umer, Nicole;B?umer, Sebastian;Becht, Manuel;Berdel, Wolfgang E.;Dersch, Petra;Faust, Andreas;Geyer, Christiane;Greune, Lilo;Lenz, Georg;Margeta, Renato;Rüter, Christian;Schlütermann, Alina;Wittmann, Lisa [Angewandte Chemie - International Edition,2022,vol. 61,# 1,art. no. E202109769][Angew. Chem.,2022,vol. 134,# 1] Location in patent:supporting information
![3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine](/CAS/GIF/1022150-12-4.gif)
1022150-12-4
246 suppliers
$180.00/1g
1553977-42-6
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143900-44-1
536 suppliers
$5.00/1g
1553977-42-6
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![4-Aminopyrazolo[3,4-d]pyrimidine](/CAS/GIF/2380-63-4.gif)
2380-63-4
360 suppliers
$9.00/1g
1553977-42-6
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940890-90-4
40 suppliers
$68.00/250mg
1553977-42-6
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