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diethyl (2-chloro-2-oxoethyl)phosphonate synthesis

5synthesis methods
3095-95-2 Synthesis
DIETHYLPHOSPHONOACETIC ACID

3095-95-2
200 suppliers
$6.00/1g

diethyl (2-chloro-2-oxoethyl)phosphonate

34170-81-5
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Yield:34170-81-5 100%

Reaction Conditions:

with oxalyl dichloride;N,N-dimethyl-formamide in benzene; for 1 h;

References:

Song, Yongcheng;Liu, Chia-I.;Lin, Fu-Yang;Joo, Hwan No;Hensler, Mary;Liu, Yi-Liang;Jeng, Wen-Yih;Low, Jennifer;Liu, George Y.;Nizet, Victor;Wang, Andrew H.-J.;Oldfield, Eric [Journal of Medicinal Chemistry,2009,vol. 52,# 13,p. 3869 - 3880] Location in patent:experimental part