ChemicalBook CAS DataBase List Donepezil Impurity-OH

Donepezil Impurity-OH synthesis

5synthesis methods

Product Name:Donepezil Impurity-OH
CAS Number:148517-82-2
Molecular formula:C11H12O4
Molecular Weight:208.21

1H-Inden-1-one, 3-bromo-2,3-dihydro-5,6-dimethoxy-

537690-41-8
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148517-82-2
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Yield: 79.2%

Reaction Conditions:

with water;potassium carbonate in tetrahydrofuran for 2 h;Reflux;Reagent/catalyst;

Steps:

1
At room temperature, the compound I (10.0g, 37mmol) was added to 300ml of water, tetrahydrofuran was added 100ml, was added potassium carbonate (25.5g, 184mmol), the reaction was warmed to reflux for 2h, turning off the heating, cooling to room temperature, dichloromethane (150ml * 3) extracted with saturated sodium chloride solution (200ml), dried over anhydrous sodium sulfate, the organic phase by rotary evaporation under reduced pressure and separated by column chromatography (dichloromethane: acetone = 100: 15) to give compound II (6.1g, 79.2%).

References:

Weihai Disu Pharmaceutical Co., Ltd.;Disha Pharmaceutical Group Co., Ltd.;Liang Songjun;He Tian;Liu Fei;Li Lulu;Miao Huaming;Cai Yahui CN106631989, 2017, A Location in patent:Paragraph 0016

111-34-2 Synthesis