ChemicalBook CAS DataBase List Sulfometuron-methyl

Sulfometuron-methyl synthesis

4synthesis methods

Product Name:Sulfometuron-methyl
CAS Number:74222-97-2
Molecular formula:C15H16N4O5S
Molecular Weight:364.38

Sulfometuron-methyl is produced by reaction of 2-sulfonylisocyanate methylbenzoate with 2-amino-4,6-dimethylpyrimidine.

767-15-7 Synthesis

767-15-7
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$5.00/1g

26638-43-7 Synthesis

26638-43-7
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$7.00/250mg

74222-97-2
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$98.00/25mg

Yield:74222-97-2 98%

Reaction Conditions:

in acetonitrile

Steps:

1 Preparation of 2-[[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester
EXAMPLE 1 Preparation of 2-[[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester A slurry of 7.0 grams (0.057 moles) of 4,6-dimethyl-2-pyrimidinamine, 6.0 grams (0.092 moles) sodium cyanate, and 13.5 grams (0.057 moles) 2-carbomethoxybenzenesulfonyl chloride in 60 ml acetonitrile was stirred 1 hour at reflux (81°). The reaction was diluted with 60 ml water, allowed to cool to room temperature and filtered. The solid was washed with 20 ml water and dried. There was obtained 16.0 grams (77.0% of theory) of the title compound. The product was 98% pure as assayed by high pressure liquid chromatography. The m.p. and IR spectrum of the title compound were identical to those of an authentic sample prepared as described in U.S. Pat. No. 4,394,506.

References:

E. I. Du Pont de Nemours and Company US4546179, 1985, A

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767-15-7 Synthesis

767-15-7
363 suppliers
$5.00/1g