Ethanone, 1-(2-amino-6-benzothiazolyl)- (9CI) synthesis
- Product Name:Ethanone, 1-(2-amino-6-benzothiazolyl)- (9CI)
- CAS Number:21222-61-7
- Molecular formula:C9H8N2OS
- Molecular Weight:192.24
333-20-0
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99-92-3
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21222-61-7
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Yield:21222-61-7 78%
Reaction Conditions:
with bromine;acetic acid at 20; for 12 h;Inert atmosphere;
Steps:
7.1 Step 1 : l-(2-aminobenzo[d]thiazol-6-yl)ethanone
A mixture of l-(4-aminophenyl)ethanone (1.35 g, 10 mmol) and potassium thiocyanate (3.9 g, 40 mmol) in acetic acid (50 mL) was added bromine (1.59 g, 10 mmol) slowly in nitrogen atmosphere, the mixture was stirred for 12 hours at room temperature. Saturated sodium chloride solution (10 mL) was added to quench the reaction. Ammonia was added to adjust the pH to 7-8 and then the mixture was filtered to give A66-1 as a yellow solid (1.5 g, 78 %). 1H NMR (400 MHz, DMSO-cfe) δ 8.32 (s, 1H), 7.91 (s, 2H), 7.83(d, / = 12.8 Hz, 1H), 7.36(d, / = 8.4 Hz, 1H), 2.54(s, 3H).
References:
WO2018/17435,2018,A1 Location in patent:Paragraph 00146-00147
540-72-7
414 suppliers
$13.50/100G
99-92-3
511 suppliers
$6.00/10g
21222-61-7
35 suppliers
$90.00/100mg
99-92-3
511 suppliers
$6.00/10g
21222-61-7
35 suppliers
$90.00/100mg
14505-89-6
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21222-61-7
35 suppliers
$90.00/100mg