ChemicalBook CAS DataBase List 4-Aminoacetophenone

4-Aminoacetophenone synthesis

11synthesis methods

Product Name:4-Aminoacetophenone
CAS Number:99-92-3
Molecular formula:C8H9NO
Molecular Weight:135.16

the synthesis of a 4-Aminoacetophenone is include:

(1) parahydroxyacet-ophenone and 2-halogen-2-methyl propanamide reacts under alkaline condition and generates 2-(4-acetyl phenoxy group)-2-methyl propanamide;

(2) 2-(4-acetyl phenoxy group)-2-methyl propanamide generates N-(4-acetyl phenyl)-2-hydroxy-2-methyl propionic acid amide through the Smiles rearrangement reaction under alkaline condition;

(3) N-(4-acetyl phenyl)-2-hydroxy-2-methyl propionic acid amide generates para-aminoacetophenone through the heating hydrolysis reaction under alkaline condition.

100-19-6
303 suppliers
$5.00/5g

99-92-3
507 suppliers
$6.00/10g

589-16-2
223 suppliers
$10.00/1g

Yield:99-92-3 95%

Reaction Conditions:

with hydrogen in glycerol at 100; for 2 h;

Steps:

2.2. Pd-catalysed hydrogenation
General procedure: 1 mmol of alkene (146 mg for (E)-4-phenyl-but-3-en-2-one;146 mg for coumarin; 165 mg for 4-nitroacetophenone; 180 mg fortrans-stilbene) was added to a 1 mL of solution of preformed nanoparticlesin glycerol (0.01 mmol Pd, 1.0 mol%). The resulting mixture was stirred at room temperature under argon in a Fisher-Porter bottle. The system was then pressurized with dihydrogen (3 bar) and stirred at100 °C for 3 h. The mixture was then cooled to room temperature. The catalytic mixture was extracted with dichloromethane (3 × 10 mL) and the combined organic phases were dried over anhydrous Na2SO4,filtered and the solvent evaporated under reduced pressure.

References:

Chahdoura, Faouzi;Favier, Isabelle;Pradel, Christian;Mallet-Ladeira, Sonia;Gómez, Montserrat [Catalysis Communications,2015,vol. 63,p. 47 - 51]

20062-24-2 Synthesis