ChemicalBook CAS DataBase List Ethanone, 2-fluoro-1-(4-fluorophenyl)- (9CI)

Ethanone, 2-fluoro-1-(4-fluorophenyl)- (9CI) synthesis

13synthesis methods

Product Name:Ethanone, 2-fluoro-1-(4-fluorophenyl)- (9CI)
CAS Number:369-41-5
Molecular formula:C8H6F2O
Molecular Weight:156.13

403-29-2 Synthesis

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Ethanone, 2-fluoro-1-(4-fluorophenyl)- (9CI)

369-41-5
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Yield: 83%

Reaction Conditions:

with tetrabutyl ammonium fluoride in water at 100; for 0.333333 h;

Steps:

4.2 Typical procedure for the preparation of 2-fluoro-1-phenylethanone (2a)
General procedure: To a flask containing water (3 mL) and TBAF·3H₂O (3 mmol) was added 2-bromo-1-phenyl ethanone (1a, 1 mmol). The mixture was stirred at 100 °C for 20 min. It was then cooled to room temperature and extracted with diethyl ether (5 mL 3×). The combined organic phases were dried, filtered and concentrated under vacuum. The residue was purified by column chromatography on silica gel eluting with ethyl acetate/hexane (5%) to give 2-fluoro-1-phenyl ethanone (2a). 2b-2k were obtained in a similar manner.

References:

He, Yan;Zhang, Xinying;Shen, Nana;Fan, Xuesen [Journal of Fluorine Chemistry,2013,vol. 156,p. 9 - 14]