ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE synthesis
- Product Name:ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE
- CAS Number:43088-42-2
- Molecular formula:C8H11NO2S
- Molecular Weight:185.24
105-56-6
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67-64-1
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43088-42-2
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$5.00/250mg
Yield:43088-42-2 76%
Reaction Conditions:
with morpholine;sulfur in ethanol at 90;Gewald reaction;
Steps:
Typical procedure for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate1a (2a):
General procedure: A mixture of cyclohexanone (1.06 mL, 10 mmol), ethyl cyanoacetate (1.15 mL, 10 mmol), morpholine (0.90 mL, 10 mmol), sulphur (0.32 g, 10 mmol) in ethanol (10 mL) was stirred and refluxed for overnight. After completion of the reaction, the reaction mixture was cooled to room temperature and the solvent was removed under vacuum. The crude solid was washed with cold ethanol and filtered though sintered funnel, dried under vacuum. The crude product was dissolved in dichloromethane and washed with brine. The organic layer was collected and concentrated under low vacuum to give the compound 2a; yield: 73% (1.83 g);
References:
Nakhi, Ali;Adepu, Raju;Rambabu;Kishore, Ravada;Vanaja;Kalle, Arunasree M.;Pal, Manojit [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 13,p. 4418 - 4427] Location in patent:supporting information; experimental part
109-89-7
440 suppliers
$10.00/5g
105-56-6
432 suppliers
$10.00/5ml
67-64-1
6 suppliers
$17.30/10ml
43088-42-2
168 suppliers
$5.00/250mg