ETHYL (5-BROMO-1H-BENZIMIDAZOL-2-YL)ACETATE synthesis
- Product Name:ETHYL (5-BROMO-1H-BENZIMIDAZOL-2-YL)ACETATE
- CAS Number:944903-92-8
- Molecular formula:C11H11BrN2O2
- Molecular Weight:283.12
Yield:944903-92-8 99%
Reaction Conditions:
with hydrogenchloride in ethyl acetate; for 2 h;Reflux;
Steps:
12
To a solution of Compound 37 (1.62 g, 6.86 mmol) in ethanol (40 mL) was added 4N hydrochloric acid (ethyl acetate solution) (17.16 ml, 68.6 mmol), then the reaction mixture was refluxed for 2 hours. The part of the solvent was removed under reduced pressure. To the reaction solution was added 10% aqueous sodium bicarbonate solution, then the reaction solution was extracted with ethyl acetate. The extraction was washed respectively with water and brine, then dried over magnesium sulfate. The solvent was removed under reduced pressure, then the obtained residue was purified by column chromatography to give Compound 38 (1.92 g, 99%). Compound 38; 1H-NMR (CDCl3) δ: 1.33 (t, J=7.2 Hz, 3H), 4.06 (s, 2H), 4.27 (q, J=7.2 Hz, 2H), 7.35 (d, J=6.3 Hz, 2H), 10.42 (brs, 1H)
References:
US2012/253040,2012,A1 Location in patent:Page/Page column 33
1575-37-7
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