Lercanidipine hydrochloride synthesis
- Product Name:Lercanidipine hydrochloride
- CAS Number:132866-11-6
- Molecular formula:C36H42ClN3O6
- Molecular Weight:648.19
100427-26-7
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132866-11-6
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Yield:132866-11-6 90%
Reaction Conditions:
with hydrogenchloride in diethyl ether;tert-butyl methyl etherProduct distribution / selectivity;
Steps:
3B
1.1 eq. of 2N HCl in Et2O was added dropwise under stirring to a solution of 1 g of lercanidipine free base in 20 mL of MTBE. The precipitate formed was filtered under vacuum, rinsed with MTBE and dried under vacuum (0.15 mmHg) at 300C for 4h affording a dry powder (Yield: 90%), HPLC assay: 99,6%.
References:
RECORDATI IRELAND LIMITED WO2008/15248, 2008, A1 Location in patent:Page/Page column 7
21731-17-9
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132866-11-6
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929212-20-4
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14205-39-1
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132866-11-6
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890045-70-2
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28075-29-8
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132866-11-6
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100442-33-9
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132866-11-6
349 suppliers
$5.00/1mg