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Lercanidipine hydrochloride

CAS No.
132866-11-6
Chemical Name:
Lercanidipine hydrochloride
Synonyms
LERCANIDIPINE HCL;CLAP;mE10;R 75;BCL10;c-E10;CIPER;CarMen;Lercan;LerzaM
CBNumber:
CB0371085
Molecular Formula:
C36H42ClN3O6
Molecular Weight:
648.19
MDL Number:
MFCD07773089
MOL File:
132866-11-6.mol
MSDS File:
SDS
Last updated:2024-03-13 13:59:12

Lercanidipine hydrochloride Properties

Melting point 175-177°C
storage temp. 2-8°C
solubility Methanol[soluble in]
solubility soluble in Methanol
form powder
color yellow
Merck 14,5446
InChIKey WMFYOYKPJLRMJI-UHFFFAOYSA-N
CAS DataBase Reference 132866-11-6(CAS DataBase Reference)
FDA UNII OA8TFX68PE

Pharmacokinetic data

Protein binding >98%
Excreted unchanged in urine 50 (as metabolites)
Biological half-life 8-10 / Increased

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  36/37-45
RIDADR  UN 2811
WGK Germany  3
HS Code  2933.39.4100
Toxicity LD50 in mice (mg/kg): 83 i.p.; 657 orally (Nardi)
NFPA 704
0
2 0

Lercanidipine hydrochloride price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L6668 Lercanidipine hydrochloride ≥98% (HPLC) 132866-11-6 10mg $122.4 2024-03-01 Buy
Sigma-Aldrich L6668 Lercanidipine hydrochloride ≥98% (HPLC) 132866-11-6 50mg $643 2024-03-01 Buy
TCI Chemical L0282 Lercanidipine Hydrochloride >98.0%(HPLC)(T) 132866-11-6 200mg $16 2024-03-01 Buy
TCI Chemical L0282 Lercanidipine Hydrochloride >98.0%(HPLC)(T) 132866-11-6 1g $44 2024-03-01 Buy
Alfa Aesar H36728 Lercanidipine hydrochloride 98% 132866-11-6 1g $327.65 2024-03-01 Buy
Product number Packaging Price Buy
L6668 10mg $122.4 Buy
L6668 50mg $643 Buy
L0282 200mg $16 Buy
L0282 1g $44 Buy
H36728 1g $327.65 Buy

Lercanidipine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Pale-Yellow Powder

Uses

long-acting dihydropyridine calcium channel blocker, antihypertensive

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Definition

ChEBI: Lercanidipine hydrochloride is a diarylmethane.

brand name

Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).

Biological Activity

L-type Ca 2+ channel blocker that displays higher vascular selectivity than Felodipine (4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester ). Causes peripheral vasodilation with only weak negative inotropic activity. Antihypertensive.

Biochem/physiol Actions

Lercanidipine hydrochloride is a L-type (Cav1.2b) vascular channel antagonist; L-type (Cav1.2a) cardiac channel agonist voltage-dependent and highly lipophylic compound, which exhibits a slower onset and longer duration of action than other calcium channel antagonists; an antihypertensive agent in patients with mild-to-moderate hypertension; more vasoselective than lacidipine and amlodipine.

100427-26-7
132866-11-6
Synthesis of Lercanidipine hydrochloride from Lercanidipine
Global( 359)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5993 58
Shanghai Affida new material science and technology center
+undefined15081010295 2691956269@qq.com China 359 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106 sales@frappschem.com China 885 50
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58

View Lastest Price from Lercanidipine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lercanidipine hydrochloride pictures 2024-03-13 Lercanidipine hydrochloride
132866-11-6
US $0.00-0.00 / kg 1kg 99 20 tons Shanghai Affida new material science and technology center
Lercanidipine hydrochloride pictures 2023-10-07 Lercanidipine hydrochloride
132866-11-6
US $0.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
Lercanidipine hydrochloride pictures 2023-10-07 Lercanidipine hydrochloride
132866-11-6
US $0.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride LERCANIDIPINE HYDROCHLORIDE 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimeth 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester Hydrochloride 3-(1-((3,3-Diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,3-[2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl] 5-Methyl ester,hydrochloride (1:1) 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester 3,5-pyridinedicarboxylic acid hydrochloride B-cell CLL/lymphoma 10 B-cell lymphoma/leukemia 10 BCL10 CARD-containing molecule enhancing NF-κ-B BCL-10 human c-E10 CIPER CLAP mE10 LERCANIDIPINEHYDROCHLORIDE(FORR&DONLY) Lercanidipine hemihydrate hydrochloride 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-[2-[3,3-diphenylpropyl(methyl)amino]-1,1-dimethyl-ethyl] ester O5-methyl ester hydrochloride 3-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride O3-[1-[3,3-diphenylpropyl(methyl)amino]-2-methyl-propan-2-yl] O5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride Lercaridipine Cardiovasc CarMen Corifeo Lercadip Lercan Lercapin Lercaton LerkaMen LerzaM R 75 Renovia Vasodip Zandip Zanicor Lercanidipine hydrochloride heMihydrate 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3,5- Lercanidipine Impurity 1 Lercanidipine hydrochloride hemihydrate, ≥98% (HPLC) -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride -2-methylpropan-2-yl) 3-(1-((3,3-Diphenylpropyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl) LercanidipineHydrochloride> ercanidipine hydrochL Lercanidipine hydrochloride USP/EP/BP Lercanidipine HCL WS Lercanidipine HCl (REC 15-237, Lercadip, Lerdip, Zanidip) Lercanidipine HydrochlorideQ: What is Lercanidipine Hydrochloride Q: What is the CAS Number of Lercanidipine Hydrochloride Q: What is the storage condition of Lercanidipine Hydrochloride Q: What are the applications of Lercanidipine Hydrochloride TIANFU CHEM Lercanidipine hydrochloride NSC 405365 NSC405365 NSC-405365 LERCANIDIPINE HCL Lercanidipine HCL Powder USP Standard Lercanidpine Hydrochoride Lecardipine hydrochloride